Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 823838..824315 Replicon chromosome
Accession NC_017343
Organism Staphylococcus aureus subsp. aureus ECT-R 2

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag ECTR2_RS03965 Protein ID WP_000052076.1
Coordinates 823838..824026 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag ECTR2_RS03970 Protein ID WP_001059690.1
Coordinates 824055..824315 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECTR2_RS03935 819832..820353 + 522 WP_000824482.1 hypothetical protein -
ECTR2_RS03940 820694..821380 + 687 WP_000141557.1 thermonuclease family protein -
ECTR2_RS03945 821737..821937 + 201 WP_001059081.1 cold-shock protein -
ECTR2_RS03950 822429..822647 - 219 WP_000005886.1 hypothetical protein -
ECTR2_RS03955 822709..822993 - 285 WP_001004399.1 hypothetical protein -
ECTR2_RS03960 823081..823650 - 570 WP_001106658.1 hypothetical protein -
ECTR2_RS03965 823838..824026 - 189 WP_000052076.1 hypothetical protein Toxin
ECTR2_RS03970 824055..824315 - 261 WP_001059690.1 hypothetical protein Antitoxin
ECTR2_RS03975 824656..824859 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
ECTR2_RS03980 824856..825092 - 237 WP_000349581.1 hypothetical protein -
ECTR2_RS03985 825317..825898 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
ECTR2_RS03990 825971..826588 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
ECTR2_RS03995 826743..827237 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
ECTR2_RS04000 827636..828058 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
ECTR2_RS04005 828206..828922 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T26682 WP_000052076.1 NC_017343:c824026-823838 [Staphylococcus aureus subsp. aureus ECT-R 2]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T26682 NC_017343:c824026-823838 [Staphylococcus aureus subsp. aureus ECT-R 2]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT26682 WP_001059690.1 NC_017343:c824315-824055 [Staphylococcus aureus subsp. aureus ECT-R 2]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT26682 NC_017343:c824315-824055 [Staphylococcus aureus subsp. aureus ECT-R 2]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References