Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | TsaAT/- |
Location | 823838..824315 | Replicon | chromosome |
Accession | NC_017343 | ||
Organism | Staphylococcus aureus subsp. aureus ECT-R 2 |
Toxin (Protein)
Gene name | TsaT | Uniprot ID | T1Y7S2 |
Locus tag | ECTR2_RS03965 | Protein ID | WP_000052076.1 |
Coordinates | 823838..824026 (-) | Length | 63 a.a. |
Antitoxin (Protein)
Gene name | TsaA | Uniprot ID | T1Y6P8 |
Locus tag | ECTR2_RS03970 | Protein ID | WP_001059690.1 |
Coordinates | 824055..824315 (-) | Length | 87 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
ECTR2_RS03935 | 819832..820353 | + | 522 | WP_000824482.1 | hypothetical protein | - |
ECTR2_RS03940 | 820694..821380 | + | 687 | WP_000141557.1 | thermonuclease family protein | - |
ECTR2_RS03945 | 821737..821937 | + | 201 | WP_001059081.1 | cold-shock protein | - |
ECTR2_RS03950 | 822429..822647 | - | 219 | WP_000005886.1 | hypothetical protein | - |
ECTR2_RS03955 | 822709..822993 | - | 285 | WP_001004399.1 | hypothetical protein | - |
ECTR2_RS03960 | 823081..823650 | - | 570 | WP_001106658.1 | hypothetical protein | - |
ECTR2_RS03965 | 823838..824026 | - | 189 | WP_000052076.1 | hypothetical protein | Toxin |
ECTR2_RS03970 | 824055..824315 | - | 261 | WP_001059690.1 | hypothetical protein | Antitoxin |
ECTR2_RS03975 | 824656..824859 | + | 204 | WP_000145163.1 | sterile alpha motif-like domain-containing protein | - |
ECTR2_RS03980 | 824856..825092 | - | 237 | WP_000349581.1 | hypothetical protein | - |
ECTR2_RS03985 | 825317..825898 | + | 582 | WP_001140693.1 | phosphoglycerate mutase family protein | - |
ECTR2_RS03990 | 825971..826588 | - | 618 | WP_000255551.1 | LysE/ArgO family amino acid transporter | - |
ECTR2_RS03995 | 826743..827237 | - | 495 | WP_000569884.1 | GNAT family N-acetyltransferase | - |
ECTR2_RS04000 | 827636..828058 | - | 423 | WP_000974460.1 | organic hydroperoxide resistance protein | - |
ECTR2_RS04005 | 828206..828922 | + | 717 | WP_000150011.1 | type I 3-dehydroquinate dehydratase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7142.82 Da Isoelectric Point: 9.9971
>T26682 WP_000052076.1 NC_017343:c824026-823838 [Staphylococcus aureus subsp. aureus ECT-R 2]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
Download Length: 189 bp
>T26682 NC_017343:c824026-823838 [Staphylococcus aureus subsp. aureus ECT-R 2]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA
Antitoxin
Download Length: 87 a.a. Molecular weight: 9940.09 Da Isoelectric Point: 4.0624
>AT26682 WP_001059690.1 NC_017343:c824315-824055 [Staphylococcus aureus subsp. aureus ECT-R 2]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
Download Length: 261 bp
>AT26682 NC_017343:c824315-824055 [Staphylococcus aureus subsp. aureus ECT-R 2]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0E0VP18 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0E0VN56 |