Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2489030..2489507 Replicon chromosome
Accession NC_017342
Organism Staphylococcus aureus subsp. aureus TCH60

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag HMPREF0772_RS12560 Protein ID WP_000052076.1
Coordinates 2489319..2489507 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag HMPREF0772_RS12555 Protein ID WP_001059690.1
Coordinates 2489030..2489290 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HMPREF0772_RS12520 2484421..2485137 - 717 WP_000150025.1 type I 3-dehydroquinate dehydratase -
HMPREF0772_RS12525 2485285..2485707 + 423 WP_000974455.1 organic hydroperoxide resistance protein -
HMPREF0772_RS12530 2486106..2486600 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
HMPREF0772_RS12535 2486757..2487374 + 618 WP_000255548.1 LysE/ArgO family amino acid transporter -
HMPREF0772_RS12540 2487447..2488028 - 582 WP_001140696.1 phosphoglycerate mutase family protein -
HMPREF0772_RS12545 2488253..2488489 + 237 WP_000368687.1 hypothetical protein -
HMPREF0772_RS12550 2488486..2488689 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
HMPREF0772_RS12555 2489030..2489290 + 261 WP_001059690.1 hypothetical protein Antitoxin
HMPREF0772_RS12560 2489319..2489507 + 189 WP_000052076.1 hypothetical protein Toxin
HMPREF0772_RS12565 2489695..2490264 + 570 WP_001106663.1 hypothetical protein -
HMPREF0772_RS12570 2490352..2490636 + 285 WP_001004401.1 hypothetical protein -
HMPREF0772_RS12575 2490698..2490916 + 219 WP_000005879.1 hypothetical protein -
HMPREF0772_RS12580 2491413..2491613 - 201 WP_001059082.1 cold-shock protein -
HMPREF0772_RS12585 2491970..2492656 - 687 WP_001574556.1 thermonuclease family protein -
HMPREF0772_RS12590 2492997..2493554 - 558 WP_000824491.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2461383..2494910 33527


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(88-134)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T26681 WP_000052076.1 NC_017342:2489319-2489507 [Staphylococcus aureus subsp. aureus TCH60]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T26681 NC_017342:2489319-2489507 [Staphylococcus aureus subsp. aureus TCH60]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTCGGATTCGCTATTTTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT26681 WP_001059690.1 NC_017342:2489030-2489290 [Staphylococcus aureus subsp. aureus TCH60]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT26681 NC_017342:2489030-2489290 [Staphylococcus aureus subsp. aureus TCH60]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References