Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF-MazE
Location 102182..102762 Replicon plasmid unnamed1
Accession NZ_CP114768
Organism Hymenobacter canadensis strain PAMC 29467

Toxin (Protein)


Gene name mazE Uniprot ID -
Locus tag O3303_RS19785 Protein ID WP_269562165.1
Coordinates 102182..102514 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name mazF Uniprot ID -
Locus tag O3303_RS19790 Protein ID WP_269562166.1
Coordinates 102502..102762 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O3303_RS19765 (O3303_19765) 98042..99139 + 1098 WP_269562161.1 HlyD family efflux transporter periplasmic adaptor subunit -
O3303_RS19770 (O3303_19770) 99142..100383 + 1242 WP_269562162.1 FtsX-like permease family protein -
O3303_RS19775 (O3303_19775) 100387..101064 + 678 WP_269562163.1 ABC transporter ATP-binding protein -
O3303_RS19780 (O3303_19780) 101629..101868 - 240 WP_269562164.1 hypothetical protein -
O3303_RS19785 (O3303_19785) 102182..102514 - 333 WP_269562165.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
O3303_RS19790 (O3303_19790) 102502..102762 - 261 WP_269562166.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
O3303_RS19795 (O3303_19795) 103088..103678 + 591 WP_269562167.1 hypothetical protein -
O3303_RS19800 (O3303_19800) 104040..104354 - 315 WP_269562168.1 hypothetical protein -
O3303_RS19805 (O3303_19805) 104351..104599 - 249 WP_269562169.1 hypothetical protein -
O3303_RS19810 (O3303_19810) 104806..105612 - 807 WP_269562170.1 LytTR family DNA-binding domain-containing protein -
O3303_RS19815 (O3303_19815) 105674..106762 - 1089 WP_269562171.1 histidine kinase -
O3303_RS19820 (O3303_19820) 106811..107209 - 399 WP_269562172.1 STAS/SEC14 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..377776 377776


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12521.45 Da        Isoelectric Point: 9.2419

>T266805 WP_269562165.1 NZ_CP114768:c102514-102182 [Hymenobacter canadensis]
MAVVGVQRFEVWLINLDPTQGSEINKTRPCVVLSPDEMNRYLRTVTIAALTSTRRDYPSRVDCTFQGKEGQVALDHIRSV
DKTRLVRRLGVLPKATAQAVCDRLQEIFQY

Download         Length: 333 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9852.12 Da        Isoelectric Point: 4.4297

>AT266805 WP_269562166.1 NZ_CP114768:c102762-102502 [Hymenobacter canadensis]
MNTRLIRVGNSQGIVLPKKLLQQYNLTGEVDLQPTPEGLLIKPVVKTRRQGWDERFQQAIAQGQAPEGELLEGFSDEAFE
ETEWQW

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References