266803

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 5157000..5157608 Replicon chromosome
Accession NZ_CP114761
Organism Pseudomonas aeruginosa strain NF143349

Toxin (Protein)


Gene name PfiT Uniprot ID -
Locus tag O4M85_RS24205 Protein ID WP_016263850.1
Coordinates 5157000..5157347 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag O4M85_RS24210 Protein ID WP_003114155.1
Coordinates 5157357..5157608 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O4M85_RS24175 (O4M85_24175) 5152359..5152631 + 273 WP_019725834.1 cysteine-rich CWC family protein -
O4M85_RS24180 (O4M85_24180) 5152631..5153323 + 693 WP_003098362.1 16S rRNA pseudouridine(516) synthase -
O4M85_RS24185 (O4M85_24185) 5153459..5154502 + 1044 WP_003098363.1 L,D-transpeptidase -
O4M85_RS24190 (O4M85_24190) 5154582..5155319 + 738 WP_003114158.1 murein L,D-transpeptidase catalytic domain family protein -
O4M85_RS24195 (O4M85_24195) 5155771..5156673 + 903 WP_003123042.1 (R)-3-hydroxydecanoyl-ACP:CoA transacylase -
O4M85_RS24205 (O4M85_24205) 5157000..5157347 - 348 WP_016263850.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
O4M85_RS24210 (O4M85_24210) 5157357..5157608 - 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
O4M85_RS24215 (O4M85_24215) 5157822..5158805 - 984 WP_019725833.1 tyrosine-type recombinase/integrase -
O4M85_RS24220 (O4M85_24220) 5158805..5160097 - 1293 WP_003115206.1 hypothetical protein -
O4M85_RS24225 (O4M85_24225) 5160356..5161618 - 1263 WP_019725831.1 zonular occludens toxin domain-containing protein -
O4M85_RS24230 (O4M85_24230) 5161620..5161970 - 351 WP_019725830.1 DUF2523 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage catB7 - 5157000..5179143 22143


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13046.85 Da        Isoelectric Point: 4.4212

>T266803 WP_016263850.1 NZ_CP114761:c5157347-5157000 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLVPFQGEQAAFQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEVAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT266803 WP_003114155.1 NZ_CP114761:c5157608-5157357 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References