Detailed information of TA system TA266798

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Acetyltransf_4(toxin)
• Location: 2008394..2009902
• Replicon: chromosome
• Accession: NZ_CP114761
• Organism: Pseudomonas aeruginosa strain NF143349

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: O4M85_RS09310
• Protein ID: WP_012613851.1
• Coordinates: 2008394..2008981 (+)
• Length: 196 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: O4M85_RS09315
• Protein ID: WP_019726549.1
• Coordinates: 2009048..2009902 (+)
• Length: 285 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
O4M85_RS09305 (O4M85_09305)	2004649..2008128	-	3480	WP_003117605.1	PAS domain-containing hybrid sensor histidine kinase/response regulator	-
O4M85_RS09310 (O4M85_09310)	2008394..2008981	+	588	WP_012613851.1	GNAT family protein	Toxin
O4M85_RS09315 (O4M85_09315)	2009048..2009902	+	855	WP_019726549.1	AraC family transcriptional regulator	Antitoxin
O4M85_RS09320 (O4M85_09320)	2009999..2012164	+	2166	WP_003091606.1	TonB-dependent receptor family protein	-
O4M85_RS09325 (O4M85_09325)	2012339..2014213	+	1875	WP_019726548.1	MFS transporter	-
O4M85_RS09330 (O4M85_09330)	2014273..2014482	-	210	WP_003115568.1	cold-shock protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (20-152)

Antitoxin

• AraC-type arabinose-binding/dimerisation domain (19-151)

Sequences

Toxin

Protein

• Length: 196 a.a.
• Molecular weight: 21929.29 Da
• Isoelectric Point: 9.8676

>T266798 WP_012613851.1 NZ_CP114761:2008394-2008981 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAVLEASFTG

Nucleotide

• Length: 588 bp

Antitoxin

Protein

• Length: 285 a.a.
• Molecular weight: 31880.18 Da
• Isoelectric Point: 7.1639

>AT266798 WP_019726549.1 NZ_CP114761:2009048-2009902 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFCHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHADSLETQTRWRETVLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTIYE

Nucleotide

• Length: 855 bp