Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 147850..148355 Replicon chromosome
Accession NZ_CP114761
Organism Pseudomonas aeruginosa strain NF143349

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag O4M85_RS00665 Protein ID WP_003083773.1
Coordinates 147850..148131 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag O4M85_RS00670 Protein ID WP_003083775.1
Coordinates 148128..148355 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O4M85_RS00640 (O4M85_00640) 143101..144450 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
O4M85_RS00645 (O4M85_00645) 144499..145185 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
O4M85_RS00650 (O4M85_00650) 145286..146020 + 735 WP_003117208.1 GntR family transcriptional regulator -
O4M85_RS00655 (O4M85_00655) 146200..146610 + 411 WP_003101225.1 aegerolysin family protein -
O4M85_RS00660 (O4M85_00660) 146642..147550 - 909 WP_003083769.1 LysR family transcriptional regulator -
O4M85_RS00665 (O4M85_00665) 147850..148131 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
O4M85_RS00670 (O4M85_00670) 148128..148355 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
O4M85_RS00675 (O4M85_00675) 148531..149151 - 621 WP_009314940.1 hypothetical protein -
O4M85_RS00680 (O4M85_00680) 149252..149752 + 501 WP_003112629.1 LEA type 2 family protein -
O4M85_RS00685 (O4M85_00685) 149825..150166 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
O4M85_RS00690 (O4M85_00690) 150248..151675 - 1428 WP_003083784.1 GABA permease -
O4M85_RS00695 (O4M85_00695) 151844..153337 - 1494 WP_003083788.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T266797 WP_003083773.1 NZ_CP114761:c148131-147850 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT266797 WP_003083775.1 NZ_CP114761:c148355-148128 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References