Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 2560077..2560606 Replicon chromosome
Accession NZ_CP114617
Organism Enterococcus faecium strain EF0656

Toxin (Protein)


Gene name relE Uniprot ID Q3XX67
Locus tag O4N81_RS12525 Protein ID WP_002296560.1
Coordinates 2560077..2560343 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A829F3T0
Locus tag O4N81_RS12530 Protein ID WP_002296559.1
Coordinates 2560343..2560606 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O4N81_RS12495 (O4N81_12495) 2555477..2555881 - 405 WP_002287522.1 IS200/IS605-like element ISEfa4 family transposase -
O4N81_RS12500 (O4N81_12500) 2556039..2556620 + 582 Protein_2419 CBS domain-containing protein -
O4N81_RS12505 (O4N81_12505) 2556624..2557265 + 642 WP_085811560.1 ABC transporter permease -
O4N81_RS12510 (O4N81_12510) 2557262..2558179 + 918 WP_002296564.1 osmoprotectant ABC transporter substrate-binding protein -
O4N81_RS12515 (O4N81_12515) 2558176..2558847 + 672 WP_002302663.1 ABC transporter permease -
O4N81_RS12520 (O4N81_12520) 2559388..2559876 - 489 WP_002296561.1 mannosyl-glycoprotein endo-beta-N-acetylglucosamidase -
O4N81_RS12525 (O4N81_12525) 2560077..2560343 - 267 WP_002296560.1 Txe/YoeB family addiction module toxin Toxin
O4N81_RS12530 (O4N81_12530) 2560343..2560606 - 264 WP_002296559.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
O4N81_RS12535 (O4N81_12535) 2561082..2561267 + 186 WP_002296558.1 transcriptional regulator -
O4N81_RS12540 (O4N81_12540) 2561409..2563232 - 1824 WP_002294202.1 APC family permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10660.13 Da        Isoelectric Point: 9.9931

>T266791 WP_002296560.1 NZ_CP114617:c2560343-2560077 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQTNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE

Download         Length: 267 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10046.05 Da        Isoelectric Point: 4.1207

>AT266791 WP_002296559.1 NZ_CP114617:c2560606-2560343 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSSFTNID
DIDWEAL

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FCW8

Antitoxin

Source ID Structure
AlphaFold DB A0A829F3T0

References