Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 2284645..2285216 Replicon chromosome
Accession NZ_CP114617
Organism Enterococcus faecium strain EF0656

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag O4N81_RS11235 Protein ID WP_105468411.1
Coordinates 2284645..2284986 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A828ZZN9
Locus tag O4N81_RS11240 Protein ID WP_002323011.1
Coordinates 2284986..2285216 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O4N81_RS11210 (O4N81_11210) 2279855..2281189 - 1335 WP_002286788.1 ABC transporter substrate-binding protein -
O4N81_RS11215 (O4N81_11215) 2281397..2282227 + 831 WP_002286789.1 manganese catalase family protein -
O4N81_RS11220 (O4N81_11220) 2282471..2282720 - 250 Protein_2167 transposase -
O4N81_RS11225 (O4N81_11225) 2282911..2283105 - 195 WP_002297028.1 hypothetical protein -
O4N81_RS11230 (O4N81_11230) 2283610..2283795 - 186 WP_002304207.1 hypothetical protein -
O4N81_RS11235 (O4N81_11235) 2284645..2284986 - 342 WP_105468411.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
O4N81_RS11240 (O4N81_11240) 2284986..2285216 - 231 WP_002323011.1 hypothetical protein Antitoxin
O4N81_RS11245 (O4N81_11245) 2285512..2285850 + 339 WP_002306002.1 hypothetical protein -
O4N81_RS11250 (O4N81_11250) 2286055..2286630 - 576 WP_002352505.1 SOS response-associated peptidase family protein -
O4N81_RS11255 (O4N81_11255) 2286995..2287576 - 582 WP_002327433.1 TetR/AcrR family transcriptional regulator -
O4N81_RS11260 (O4N81_11260) 2287759..2288385 - 627 WP_002352507.1 cysteine hydrolase -
O4N81_RS11265 (O4N81_11265) 2288407..2289735 - 1329 WP_002327434.1 FAD-containing oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13355.73 Da        Isoelectric Point: 10.2170

>T266790 WP_105468411.1 NZ_CP114617:c2284986-2284645 [Enterococcus faecium]
VSEERIYIPKKGDIVWIDFDPSVGKEIQKRRPGLVVSRYEFNRKTMFSVIRPITSTIKNLPTRYSLPEELDIKGQVIITQ
LKSLDFKERKLKKIENLPLQDMAKIDQIIQYMF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8523.39 Da        Isoelectric Point: 3.9078

>AT266790 WP_002323011.1 NZ_CP114617:c2285216-2284986 [Enterococcus faecium]
MLVTKSRLQGSSVVVTLPSDNGKKPSENQEYIVVYSDDGTITLVPKIEDPFSGGEEAEYYEKDEWEDLTPEGREIL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZZN9

References