Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 18855..19390 Replicon plasmid pWEC-2
Accession NZ_CP114594
Organism Escherichia coli strain WEC

Toxin (Protein)


Gene name relE Uniprot ID T1PX77
Locus tag O3296_RS23425 Protein ID WP_001523468.1
Coordinates 19103..19390 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A8H9BAF4
Locus tag O3296_RS23420 Protein ID WP_021560314.1
Coordinates 18855..19106 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O3296_RS23395 (14447) 14447..14980 - 534 WP_269546240.1 transcription termination/antitermination NusG family protein -
O3296_RS23400 (15427) 15427..15714 - 288 WP_019842580.1 conjugal transfer protein TraA -
O3296_RS23405 (15752) 15752..15895 - 144 Protein_18 ash family protein -
O3296_RS23410 (16871) 16871..17902 + 1032 WP_024227073.1 plasmid replication initiator RepA -
O3296_RS23415 (18601) 18601..18768 + 168 WP_032154506.1 hypothetical protein -
O3296_RS23420 (18855) 18855..19106 + 252 WP_021560314.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
O3296_RS23425 (19103) 19103..19390 + 288 WP_001523468.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
O3296_RS23430 (19400) 19400..19945 + 546 WP_001523466.1 hypothetical protein -
O3296_RS23435 (20241) 20241..20828 + 588 WP_024229909.1 serine acetyltransferase -
O3296_RS23440 (21108) 21108..21701 - 594 WP_001523457.1 ProQ/FINO family protein -
O3296_RS23445 (22707) 22707..23471 + 765 WP_000340226.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..92065 92065


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11142.18 Da        Isoelectric Point: 10.6741

>T266779 WP_001523468.1 NZ_CP114594:19103-19390 [Escherichia coli]
MTYTVKFRDDALREWLRLDKAIQQQFAKKLKKCSENPHIASAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSHVYNLASERMR

Download         Length: 288 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9198.42 Da        Isoelectric Point: 4.0927

>AT266779 WP_021560314.1 NZ_CP114594:18855-19106 [Escherichia coli]
MPSIILSDTSASVSELKKNPMATVSAGEGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSNQPLHDVDLD
SYL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB T1PX77

Antitoxin

Source ID Structure

References