Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4202107..4202702 Replicon chromosome
Accession NZ_CP114592
Organism Escherichia coli strain WEC

Toxin (Protein)


Gene name chpB Uniprot ID V0SXT4
Locus tag O3296_RS20240 Protein ID WP_000239581.1
Coordinates 4202107..4202457 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag O3296_RS20245 Protein ID WP_001223213.1
Coordinates 4202451..4202702 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O3296_RS20220 (4197561) 4197561..4198583 - 1023 WP_063625321.1 ABC transporter permease -
O3296_RS20225 (4198597) 4198597..4200099 - 1503 WP_063625322.1 sugar ABC transporter ATP-binding protein -
O3296_RS20230 (4200232) 4200232..4201188 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
O3296_RS20235 (4201498) 4201498..4202028 + 531 WP_000055075.1 inorganic diphosphatase -
O3296_RS20240 (4202107) 4202107..4202457 - 351 WP_000239581.1 endoribonuclease toxin ChpB Toxin
O3296_RS20245 (4202451) 4202451..4202702 - 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
O3296_RS20250 (4202914) 4202914..4203255 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
O3296_RS20255 (4203258) 4203258..4207037 - 3780 WP_063625323.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12453.41 Da        Isoelectric Point: 6.2206

>T266774 WP_000239581.1 NZ_CP114592:c4202457-4202107 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT266774 WP_001223213.1 NZ_CP114592:c4202702-4202451 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SXT4

Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References