Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4190763..4191285 Replicon chromosome
Accession NZ_CP114592
Organism Escherichia coli strain WEC

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag O3296_RS20180 Protein ID WP_104773392.1
Coordinates 4190763..4191053 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0SC69
Locus tag O3296_RS20185 Protein ID WP_000212715.1
Coordinates 4191043..4191285 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O3296_RS20165 (4185931) 4185931..4187586 + 1656 WP_063625319.1 alpha,alpha-phosphotrehalase -
O3296_RS20170 (4187980) 4187980..4190118 + 2139 WP_000187798.1 anaerobic ribonucleoside-triphosphate reductase -
O3296_RS20175 (4190298) 4190298..4190762 + 465 WP_001009182.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
O3296_RS20180 (4190763) 4190763..4191053 - 291 WP_104773392.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
O3296_RS20185 (4191043) 4191043..4191285 - 243 WP_000212715.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
O3296_RS20190 (4191477) 4191477..4191863 - 387 WP_001232253.1 cytochrome b562 -
O3296_RS20195 (4191919) 4191919..4193271 - 1353 WP_063625320.1 metalloprotease PmbA -
O3296_RS20200 (4193365) 4193365..4193916 + 552 WP_000166270.1 ribosome biogenesis factor YjgA -
O3296_RS20205 (4193999) 4193999..4195372 - 1374 WP_001219792.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11367.23 Da        Isoelectric Point: 10.0238

>T266773 WP_104773392.1 NZ_CP114592:c4191053-4190763 [Escherichia coli]
MNYELAFDPRALKEWQKLGVAVREQFKKKLEDVLKRPRNPSAKLRDLPDCYKIKLRTQGYRLVYQVNDKELLVLVITIGK
RENSAVYEDATKRLDE

Download         Length: 291 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9125.56 Da        Isoelectric Point: 5.1369

>AT266773 WP_000212715.1 NZ_CP114592:c4191285-4191043 [Escherichia coli]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9H4B3

References