Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3519510..3520128 Replicon chromosome
Accession NZ_CP114592
Organism Escherichia coli strain WEC

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag O3296_RS17150 Protein ID WP_001291435.1
Coordinates 3519910..3520128 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag O3296_RS17145 Protein ID WP_000344800.1
Coordinates 3519510..3519884 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O3296_RS17135 (3514599) 3514599..3515792 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
O3296_RS17140 (3515815) 3515815..3518964 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
O3296_RS17145 (3519510) 3519510..3519884 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
O3296_RS17150 (3519910) 3519910..3520128 + 219 WP_001291435.1 HHA domain-containing protein Toxin
O3296_RS17155 (3520300) 3520300..3520851 + 552 WP_000102564.1 maltose O-acetyltransferase -
O3296_RS17160 (3520967) 3520967..3521437 + 471 WP_000136192.1 YlaC family protein -
O3296_RS17165 (3521601) 3521601..3523151 + 1551 WP_063625273.1 cyclic-guanylate-specific phosphodiesterase PdeB -
O3296_RS17170 (3523193) 3523193..3523546 - 354 WP_000878140.1 DUF1428 domain-containing protein -
O3296_RS17180 (3523925) 3523925..3524236 + 312 WP_000409911.1 MGMT family protein -
O3296_RS17185 (3524267) 3524267..3524839 - 573 WP_000779826.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T266770 WP_001291435.1 NZ_CP114592:3519910-3520128 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT266770 WP_000344800.1 NZ_CP114592:3519510-3519884 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References