Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1307467..1308092 Replicon chromosome
Accession NZ_CP114592
Organism Escherichia coli strain WEC

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag O3296_RS06405 Protein ID WP_000911330.1
Coordinates 1307694..1308092 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag O3296_RS06400 Protein ID WP_000450524.1
Coordinates 1307467..1307694 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O3296_RS06375 (1303270) 1303270..1303740 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
O3296_RS06380 (1303740) 1303740..1304312 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
O3296_RS06385 (1304458) 1304458..1305336 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
O3296_RS06390 (1305353) 1305353..1306387 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
O3296_RS06395 (1306600) 1306600..1307313 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
O3296_RS06400 (1307467) 1307467..1307694 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
O3296_RS06405 (1307694) 1307694..1308092 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
O3296_RS06410 (1308239) 1308239..1309102 + 864 WP_001267507.1 neutral zinc metallopeptidase -
O3296_RS06415 (1309117) 1309117..1311132 + 2016 WP_000829335.1 tRNA cytosine(34) acetyltransferase TmcA -
O3296_RS06420 (1311206) 1311206..1311904 + 699 WP_000679812.1 esterase -
O3296_RS06425 (1312014) 1312014..1312214 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T266762 WP_000911330.1 NZ_CP114592:1307694-1308092 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT266762 WP_000450524.1 NZ_CP114592:1307467-1307694 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References