Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 876170..876824 Replicon chromosome
Accession NZ_CP114592
Organism Escherichia coli strain WEC

Toxin (Protein)


Gene name cptA Uniprot ID F4NJ21
Locus tag O3296_RS04290 Protein ID WP_000244772.1
Coordinates 876417..876824 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag O3296_RS04285 Protein ID WP_000354046.1
Coordinates 876170..876436 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O3296_RS04260 (871458) 871458..872201 + 744 WP_000951964.1 SDR family oxidoreductase -
O3296_RS04265 (872258) 872258..873691 - 1434 WP_001344773.1 6-phospho-beta-glucosidase BglA -
O3296_RS04270 (873736) 873736..874047 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
O3296_RS04275 (874211) 874211..874870 + 660 WP_000250274.1 hemolysin III family protein -
O3296_RS04280 (874947) 874947..875927 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
O3296_RS04285 (876170) 876170..876436 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
O3296_RS04290 (876417) 876417..876824 + 408 WP_000244772.1 protein YgfX Toxin
O3296_RS04295 (876864) 876864..877385 - 522 WP_063625410.1 flavodoxin FldB -
O3296_RS04300 (877497) 877497..878393 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
O3296_RS04305 (878418) 878418..879128 + 711 WP_000715208.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
O3296_RS04310 (879134) 879134..880867 + 1734 WP_000813220.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16048.02 Da        Isoelectric Point: 11.2511

>T266759 WP_000244772.1 NZ_CP114592:876417-876824 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT266759 WP_000354046.1 NZ_CP114592:876170-876436 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XYB4

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References