Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 292276..293076 Replicon chromosome
Accession NZ_CP114592
Organism Escherichia coli strain WEC

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag O3296_RS01345 Protein ID WP_000342451.1
Coordinates 292549..293076 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4NNI1
Locus tag O3296_RS01340 Protein ID WP_001277108.1
Coordinates 292276..292542 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O3296_RS01320 (287934) 287934..288602 + 669 WP_000617723.1 cell division ATP-binding protein FtsE -
O3296_RS01325 (288595) 288595..289653 + 1059 WP_001042003.1 permease-like cell division protein FtsX -
O3296_RS01330 (289897) 289897..290751 + 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
O3296_RS01335 (291023) 291023..292126 + 1104 WP_078167906.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
O3296_RS01340 (292276) 292276..292542 + 267 WP_001277108.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
O3296_RS01345 (292549) 292549..293076 + 528 WP_000342451.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
O3296_RS01350 (293073) 293073..293456 - 384 WP_000778795.1 aspartate 1-decarboxylase autocleavage activator PanM -
O3296_RS01355 (293880) 293880..294989 + 1110 WP_000827696.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
O3296_RS01360 (295037) 295037..295963 + 927 WP_000003004.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
O3296_RS01365 (295960) 295960..297237 + 1278 WP_000803798.1 branched chain amino acid ABC transporter permease LivM -
O3296_RS01370 (297234) 297234..298001 + 768 WP_000082110.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19749.73 Da        Isoelectric Point: 7.3232

>T266757 WP_000342451.1 NZ_CP114592:292549-293076 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLCGSCFERAELPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNKKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTQSD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9910.31 Da        Isoelectric Point: 10.0863

>AT266757 WP_001277108.1 NZ_CP114592:292276-292542 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRVILNEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6GTS
PDB 6AJN
PDB 6GTQ
PDB 6GTO
PDB 6GTR
PDB 6AJM
AlphaFold DB A0A829CN24

References