Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 319916..320564 Replicon plasmid unnamed
Accession NZ_CP114587
Organism Salinivibrio kushneri strain TGB4

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag O4598_RS14250 Protein ID WP_269601153.1
Coordinates 320163..320564 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag O4598_RS14245 Protein ID WP_077522588.1
Coordinates 319916..320149 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O4598_RS14225 (O4598_14225) 315308..317755 + 2448 WP_269600700.1 DUF2309 domain-containing protein -
O4598_RS14230 (O4598_14230) 317764..318735 + 972 WP_269600702.1 L-threonylcarbamoyladenylate synthase -
O4598_RS14235 (O4598_14235) 318746..319156 - 411 WP_269600704.1 PaaI family thioesterase -
O4598_RS14240 (O4598_14240) 319149..319661 - 513 WP_269600705.1 NifB/NifX family molybdenum-iron cluster-binding protein -
O4598_RS14245 (O4598_14245) 319916..320149 + 234 WP_077522588.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
O4598_RS14250 (O4598_14250) 320163..320564 + 402 WP_269601153.1 type II toxin-antitoxin system VapC family toxin Toxin
O4598_RS14255 (O4598_14255) 320593..320874 - 282 WP_269600708.1 DUF134 domain-containing protein -
O4598_RS14260 (O4598_14260) 320988..322436 - 1449 WP_269600709.1 decarboxylating NADP(+)-dependent phosphogluconate dehydrogenase -
O4598_RS14265 (O4598_14265) 322448..323173 - 726 WP_269600710.1 6-phosphogluconolactonase -
O4598_RS14270 (O4598_14270) 323170..324672 - 1503 WP_077458389.1 glucose-6-phosphate dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..562514 562514


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

SpoVT-AbrB domain

(7-53)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14671.08 Da        Isoelectric Point: 8.7410

>T266752 WP_269601153.1 NZ_CP114587:320163-320564 [Salinivibrio kushneri]
MLDTCICSFIMREQPKAVLKKLHTVVGNQHRIVISAITYQEMQYGLLGKKASPKHAVLVDAFLQRIDEILPWDKAAVDAT
TAVKRNLMNKGTPIGGNDTAIAGHAIATGCVLVTNNTREFQRVEGLKLEDWAQ

Download         Length: 402 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8986.11 Da        Isoelectric Point: 4.8668

>AT266752 WP_077522588.1 NZ_CP114587:319916-320149 [Salinivibrio kushneri]
MRTISIFKNGKNQAVRLPKDFEFDGVNELEIHKEGDVITLRPARPSWLSFGELEKADSDFMTHREELIKDEGRFSFD

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References