Detailed information of TA system TA266749

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 1783672..1785500
• Replicon: chromosome
• Accession: NZ_CP114586
• Organism: Salinivibrio kushneri strain TGB4

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: O4598_RS08380
• Protein ID: WP_269599265.1
• Coordinates: 1783672..1785033 (+)
• Length: 454 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: O4598_RS08385
• Protein ID: WP_269599266.1
• Coordinates: 1785030..1785500 (+)
• Length: 157 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
O4598_RS08365 (O4598_08365)	1778783..1779949	-	1167	WP_269599262.1	nucleotide sugar dehydrogenase	-
O4598_RS08370 (O4598_08370)	1780094..1780864	-	771	WP_269599263.1	Wzz/FepE/Etk N-terminal domain-containing protein	-
O4598_RS08375 (O4598_08375)	1781937..1783439	-	1503	WP_269599264.1	hypothetical protein	-
O4598_RS08380 (O4598_08380)	1783672..1785033	+	1362	WP_269599265.1	HipA domain-containing protein	Toxin
O4598_RS08385 (O4598_08385)	1785030..1785500	+	471	WP_269599266.1	helix-turn-helix transcriptional regulator	Antitoxin
O4598_RS08395 (O4598_08395)	1785944..1786522	+	579	WP_269599267.1	UPF0149 family protein	-
O4598_RS08400 (O4598_08400)	1786961..1787248	-	288	WP_021024377.1	NadS family protein	-
O4598_RS08405 (O4598_08405)	1787951..1789131	+	1181	WP_269599268.1	IS3 family transposase	-
O4598_RS08410 (O4598_08410)	1789977..1790390	+	414	WP_269599270.1	HI0074 family nucleotidyltransferase substrate-binding subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (166-394)

Antitoxin

• Cro/C1-type helix-turn-helix domain (81-139)

Sequences

Toxin

Protein

• Length: 454 a.a.
• Molecular weight: 51462.33 Da
• Isoelectric Point: 6.0005

>T266749 WP_269599265.1 NZ_CP114586:1783672-1785033 [Salinivibrio kushneri]
MEALNVQAFIKGEWTDVGTISFPKNHQHNFRVTELHYLSDYALAHHDQDDCHAVSINHPVSFFFDDLGKPGWLRFLDDIM
PSGASRRYWVKHLDIEDLSVDEQNYILLKFGTMSPIGNLRIKDSLPERYDVADNLYFSVDDVKNRAGDFLDYAQQRGAAA
GGATGAGGEAPKLVLRCGFDHRAGREKIWIDTYQDENHNHDAHYLVKYPRGSRSPIDCNILRAEFHYYHELTEMGVETIP
IDGMRLEEGLSYPSLWLPRFDVQVNHQQIERLGMESVYSMLNKGAGITLDHETTIRTLIRKITNSHTVQDQGYMFNAQEF
VIEWVKRDLLNILFGNSDNHGRNTSFLKADGVIKLAPVYDFAPMKADPEGIPRTTKWKAPLEVGGTYDFVAIADTLSDLV
PKDVLLKELKVTASKCMDLKQRLALRGVPEQILEMPAIGFNHLSQKLANWGLL

Nucleotide

• Length: 1362 bp

Antitoxin

Protein

• Length: 157 a.a.
• Molecular weight: 17369.73 Da
• Isoelectric Point: 10.3987

>AT266749 WP_269599266.1 NZ_CP114586:1785030-1785500 [Salinivibrio kushneri]
MNKPSHKESVQDVVDRLRANRSQKESTKEGETAHSINDQPQCNSPTRTKASKNTMAVSAAERKTEANKIIKRLLFGELTQ
GQALKNLRVTILGLKQDVFAKLVGISRKTLSDIENDRGSYNTEVLNKVFKPFGLQVGLLPSSPDTLRALLTEHDRD

Nucleotide

• Length: 471 bp