Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 501825..502470 Replicon plasmid unnamed
Accession NZ_CP114585
Organism Salinivibrio proteolyticus strain TGB10

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag N7E60_RS16205 Protein ID WP_069363033.1
Coordinates 502072..502470 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A1V3HTW4
Locus tag N7E60_RS16200 Protein ID WP_069363032.1
Coordinates 501825..502058 (+) Length 78 a.a.

Genomic Context

N7E60_RS16180N7E60_RS16185N7E60_RS16200N7E60_RS16205N7E60_RS16190N7E60_RS16195N7E60_RS16210N7E60_RS16215N7E60_RS16220N7E60_RS16225
Location: 497259..499706 (2448 bp)
Type: Others
Protein ID: WP_269598666.1
Location: 499715..500686 (972 bp)
Type: Others
Protein ID: WP_077675221.1
Location: 501825..502058 (234 bp)
Type: Antitoxin
Protein ID: WP_069363032.1
Location: 502072..502470 (399 bp)
Type: Toxin
Protein ID: WP_069363033.1
Location: 500679..501098 (420 bp)
Type: Others
Protein ID: WP_167315163.1
Location: 501091..501600 (510 bp)
Type: Others
Protein ID: WP_269598667.1
Location: 502502..502783 (282 bp)
Type: Others
Protein ID: WP_021023566.1
Location: 502911..504359 (1449 bp)
Type: Others
Protein ID: WP_069589412.1
Location: 504371..505096 (726 bp)
Type: Others
Protein ID: WP_269598668.1
Location: 505093..506595 (1503 bp)
Type: Others
Protein ID: WP_077662404.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
N7E60_RS16180 (N7E60_16180)497259..499706+2448WP_269598666.1DUF2309 domain-containing protein-
N7E60_RS16185 (N7E60_16185)499715..500686+972WP_077675221.1L-threonylcarbamoyladenylate synthase-
N7E60_RS16190 (N7E60_16190)500679..501098-420WP_167315163.1PaaI family thioesterase-
N7E60_RS16195 (N7E60_16195)501091..501600-510WP_269598667.1NifB/NifX family molybdenum-iron cluster-binding protein-
N7E60_RS16200 (N7E60_16200)501825..502058+234WP_069363032.1type II toxin-antitoxin system VapB family antitoxinAntitoxin
N7E60_RS16205 (N7E60_16205)502072..502470+399WP_069363033.1type II toxin-antitoxin system VapC family toxinToxin
N7E60_RS16210 (N7E60_16210)502502..502783-282WP_021023566.1DUF134 domain-containing protein-
N7E60_RS16215 (N7E60_16215)502911..504359-1449WP_069589412.1decarboxylating NADP(+)-dependent phosphogluconate dehydrogenase-
N7E60_RS16220 (N7E60_16220)504371..505096-726WP_269598668.16-phosphogluconolactonase-
N7E60_RS16225 (N7E60_16225)505093..506595-1503WP_077662404.1glucose-6-phosphate dehydrogenase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid-hcp-2 / hcp-2 / vipA/mglA / vipB/mglB / VCA0109 / vasA / vasB / vasD / vasE / vasF / clpB/vasG / vasJ / icmF/vasK / hcp-21..760770760770


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

SpoVT-AbrB domain

(7-53)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14542.95 Da        Isoelectric Point: 8.7410

>T266746 WP_069363033.1 NZ_CP114585:502072-502470 [Salinivibrio proteolyticus]
MLDTCICSFIMREQPKAVLKKLHTVVGNQHRIVISAITYQEMQYGLLGKKASPKHAVLVDAFLQRIDEILPWDKAAVDAT
TAVKRNLMNKGTPIGGNDTAIAGHAIATGCVLVTNNTREFQRVEGLKLEDWA

Download         Length: 399 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 9013.13 Da        Isoelectric Point: 4.8668

>AT266746 WP_069363032.1 NZ_CP114585:501825-502058 [Salinivibrio proteolyticus]
MRTISIFKNGKNQAVRLPKDFEFDGVNELEIHKEGDVITLRPARPSWLSFGELEKADSDFMTHREELIKDEGRFNFD

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1V3HTW4

References