Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 501825..502470 Replicon plasmid unnamed
Accession NZ_CP114585
Organism Salinivibrio proteolyticus strain TGB10

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag N7E60_RS16205 Protein ID WP_069363033.1
Coordinates 502072..502470 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A1V3HTW4
Locus tag N7E60_RS16200 Protein ID WP_069363032.1
Coordinates 501825..502058 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7E60_RS16180 (N7E60_16180) 497259..499706 + 2448 WP_269598666.1 DUF2309 domain-containing protein -
N7E60_RS16185 (N7E60_16185) 499715..500686 + 972 WP_077675221.1 L-threonylcarbamoyladenylate synthase -
N7E60_RS16190 (N7E60_16190) 500679..501098 - 420 WP_167315163.1 PaaI family thioesterase -
N7E60_RS16195 (N7E60_16195) 501091..501600 - 510 WP_269598667.1 NifB/NifX family molybdenum-iron cluster-binding protein -
N7E60_RS16200 (N7E60_16200) 501825..502058 + 234 WP_069363032.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
N7E60_RS16205 (N7E60_16205) 502072..502470 + 399 WP_069363033.1 type II toxin-antitoxin system VapC family toxin Toxin
N7E60_RS16210 (N7E60_16210) 502502..502783 - 282 WP_021023566.1 DUF134 domain-containing protein -
N7E60_RS16215 (N7E60_16215) 502911..504359 - 1449 WP_069589412.1 decarboxylating NADP(+)-dependent phosphogluconate dehydrogenase -
N7E60_RS16220 (N7E60_16220) 504371..505096 - 726 WP_269598668.1 6-phosphogluconolactonase -
N7E60_RS16225 (N7E60_16225) 505093..506595 - 1503 WP_077662404.1 glucose-6-phosphate dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - hcp-2 / hcp-2 / vipA/mglA / vipB/mglB / VCA0109 / vasA / vasB / vasD / vasE / vasF / clpB/vasG / vasJ / icmF/vasK / hcp-2 1..760770 760770


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

SpoVT-AbrB domain

(7-53)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14542.95 Da        Isoelectric Point: 8.7410

>T266746 WP_069363033.1 NZ_CP114585:502072-502470 [Salinivibrio proteolyticus]
MLDTCICSFIMREQPKAVLKKLHTVVGNQHRIVISAITYQEMQYGLLGKKASPKHAVLVDAFLQRIDEILPWDKAAVDAT
TAVKRNLMNKGTPIGGNDTAIAGHAIATGCVLVTNNTREFQRVEGLKLEDWA

Download         Length: 399 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 9013.13 Da        Isoelectric Point: 4.8668

>AT266746 WP_069363032.1 NZ_CP114585:501825-502058 [Salinivibrio proteolyticus]
MRTISIFKNGKNQAVRLPKDFEFDGVNELEIHKEGDVITLRPARPSWLSFGELEKADSDFMTHREELIKDEGRFNFD

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1V3HTW4

References