Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafN(antitoxin)
Location 261340..261905 Replicon plasmid unnamed
Accession NZ_CP114585
Organism Salinivibrio proteolyticus strain TGB10

Toxin (Protein)


Gene name relE Uniprot ID U3BCD3
Locus tag N7E60_RS15125 Protein ID WP_010377835.1
Coordinates 261340..261627 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1V3HI60
Locus tag N7E60_RS15130 Protein ID WP_021024253.1
Coordinates 261624..261905 (-) Length 94 a.a.

Genomic Context

N7E60_RS15120N7E60_RS15140N7E60_RS15100N7E60_RS15105N7E60_RS15110N7E60_RS15115N7E60_RS15125N7E60_RS15130N7E60_RS15135N7E60_RS15145N7E60_RS15150N7E60_RS15155
Location: 260300..261199 (900 bp)
Type: Others
Protein ID: WP_077669852.1
Location: 262910..263191 (282 bp)
Type: Others
Protein ID: Protein_223
Location: 257043..257687 (645 bp)
Type: Others
Protein ID: WP_077639985.1
Location: 257762..258901 (1140 bp)
Type: Others
Protein ID: WP_269598948.1
Location: 259022..259732 (711 bp)
Type: Others
Protein ID: WP_077608514.1
Location: 259739..260170 (432 bp)
Type: Others
Protein ID: WP_167315444.1
Location: 261340..261627 (288 bp)
Type: Toxin
Protein ID: WP_010377835.1
Location: 261624..261905 (282 bp)
Type: Antitoxin
Protein ID: WP_021024253.1
Location: 262003..262425 (423 bp)
Type: Others
Protein ID: WP_269598949.1
Location: 263280..264077 (798 bp)
Type: Others
Protein ID: WP_046075942.1
Location: 264575..265345 (771 bp)
Type: Others
Protein ID: WP_096631753.1
Location: 265459..266328 (870 bp)
Type: Others
Protein ID: WP_269598950.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
N7E60_RS15100 (N7E60_15100)257043..257687-645WP_077639985.1pyroglutamyl-peptidase I-
N7E60_RS15105 (N7E60_15105)257762..258901-1140WP_269598948.1peptide-methionine (R)-S-oxide reductase MsrB-
N7E60_RS15110 (N7E60_15110)259022..259732-711WP_077608514.1LrgB family protein-
N7E60_RS15115 (N7E60_15115)259739..260170-432WP_167315444.1CidA/LrgA family protein-
N7E60_RS15120 (N7E60_15120)260300..261199+900WP_077669852.1LysR family transcriptional regulator-
N7E60_RS15125 (N7E60_15125)261340..261627-288WP_010377835.1type II toxin-antitoxin system RelE/ParE family toxinToxin
N7E60_RS15130 (N7E60_15130)261624..261905-282WP_021024253.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
N7E60_RS15135 (N7E60_15135)262003..262425-423WP_269598949.1hypothetical protein-
N7E60_RS15140 (N7E60_15140)262910..263191+282Protein_223LysR substrate-binding domain-containing protein-
N7E60_RS15145 (N7E60_15145)263280..264077-798WP_046075942.1hypothetical protein-
N7E60_RS15150 (N7E60_15150)264575..265345-771WP_096631753.1hypothetical protein-
N7E60_RS15155 (N7E60_15155)265459..266328-870WP_269598950.1restriction endonuclease-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid-hcp-2 / hcp-2 / vipA/mglA / vipB/mglB / VCA0109 / vasA / vasB / vasD / vasE / vasF / clpB/vasG / vasJ / icmF/vasK / hcp-21..760770760770


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-74)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10998.68 Da        Isoelectric Point: 4.8177

>T266745 WP_010377835.1 NZ_CP114585:c261627-261340 [Salinivibrio proteolyticus]
MKVVWSPLALQKLGDAAEFISLDNPPAAEKWVNEVFDKTELLGSMPEMGRFVPEMPNTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQMLSEDDV

Download         Length: 288 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10379.86 Da        Isoelectric Point: 5.7134

>AT266745 WP_021024253.1 NZ_CP114585:c261905-261624 [Salinivibrio proteolyticus]
MSRIHFDQDIQPLSEFRAGVASYIKQINETRRPLVITQHGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLASGLGVSN
DDARAQVLGRIKK

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBU3BCD3

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1V3HI60

References