Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) rlegTA/AbiEii-AbiEi
Location 2726302..2727764 Replicon chromosome
Accession NZ_CP114578
Organism Legionella pneumophila strain A194

Toxin (Protein)


Gene name rlegT Uniprot ID -
Locus tag LpnA194_RS12145 Protein ID WP_014844517.1
Coordinates 2726302..2727159 (-) Length 286 a.a.

Antitoxin (Protein)


Gene name rlegA Uniprot ID -
Locus tag LpnA194_RS12150 Protein ID WP_014844518.1
Coordinates 2727156..2727764 (-) Length 203 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LpnA194_RS12130 (LpnA194_02436) 2721788..2723443 + 1656 WP_040146526.1 hypothetical protein -
LpnA194_RS12135 (LpnA194_02437) 2723727..2725478 - 1752 Protein_2379 DUF927 domain-containing protein -
LpnA194_RS12140 (LpnA194_02438) 2725562..2725837 - 276 WP_014844516.1 helix-turn-helix domain-containing protein -
LpnA194_RS12145 (LpnA194_02439) 2726302..2727159 - 858 WP_014844517.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
LpnA194_RS12150 (LpnA194_02440) 2727156..2727764 - 609 WP_014844518.1 AbiEi antitoxin N-terminal domain-containing protein Antitoxin
LpnA194_RS12155 (LpnA194_02441) 2727842..2728075 - 234 WP_014844519.1 hypothetical protein -
LpnA194_RS12160 (LpnA194_02442) 2728160..2729392 - 1233 WP_027268449.1 integrase family protein -
LpnA194_RS12165 (LpnA194_02443) 2729636..2730622 - 987 WP_061489033.1 IS30 family transposase -
LpnA194_RS12170 (LpnA194_02444) 2730855..2731040 + 186 WP_029345968.1 hypothetical protein -
LpnA194_RS12175 (LpnA194_02445) 2731037..2731951 + 915 WP_029345970.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2715691..2744159 28468


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(37-261)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(7-93)


Sequences

Toxin        


Download         Length: 286 a.a.        Molecular weight: 31776.77 Da        Isoelectric Point: 6.2736

>T266740 WP_014844517.1 NZ_CP114578:c2727159-2726302 [Legionella pneumophila]
MTKDISASIRARLKKIAKAEGSKSDFIAVLTRYGLERLLYRIGISEYASQFLLKGALLFNLWYDMPHRPTKDIDLLGFGD
NDLAYIQKTFREICSLSADDGMNFLSKSVEVSTIKKDGGYTGARVELFGELAKAKIKIQVDIGYGDAVTPGPIDANYPVL
LSDLPAPQIRTYPVYTVIAEKLHAIALLGMANSRLKDYLDLYVLLTQEQLDNQVLAQAIHATFIRRGMTVPEVLPVGLSD
EFANDPTRISIWNAFLSKNELEQRSLTEVIEVIISLIQTPFSLAR

Download         Length: 858 bp

Antitoxin


Download         Length: 203 a.a.        Molecular weight: 22953.73 Da        Isoelectric Point: 9.2881

>AT266740 WP_014844518.1 NZ_CP114578:c2727764-2727156 [Legionella pneumophila]
MNTKNTHSQKALNLAKEKGIVRSSEFVEEGIPRIVISRLVANQQLQQIERGLYCLPEKEFSEKESLLVIATRVPQAIFCL
FTALQVHGLTTQLPRKIWIAMPIDSRVPKIDYPPIKMVKYSGEAYSQGIETQEADGVSFRVYNVAKTIADCFKHRNKIGM
DVAIEALKDAYAQNKVTADELWHYAKICRVAKVMRPYLEAIQ

Download         Length: 609 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References