Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 70690..72227 Replicon chromosome
Accession NZ_CP114576
Organism Legionella pneumophila strain H3

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag LpnH3D14_RS00340 Protein ID WP_032830606.1
Coordinates 70690..71994 (-) Length 435 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag LpnH3D14_RS00345 Protein ID WP_014840730.1
Coordinates 71988..72227 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LpnH3D14_RS00305 (LpnH3D14_00062) 66241..67263 + 1023 WP_269565330.1 alpha/beta hydrolase -
LpnH3D14_RS00310 (LpnH3D14_00063) 67224..67487 + 264 WP_269565329.1 hypothetical protein -
LpnH3D14_RS00315 67595..67747 + 153 WP_154231767.1 hypothetical protein -
LpnH3D14_RS00320 (LpnH3D14_00064) 67784..68188 - 405 WP_011945253.1 MerR family transcriptional regulator -
LpnH3D14_RS00325 (LpnH3D14_00065) 68258..69001 + 744 WP_011945254.1 glutaredoxin family protein -
LpnH3D14_RS00330 (LpnH3D14_00066) 69200..70303 + 1104 WP_040147074.1 hypothetical protein -
LpnH3D14_RS00335 (LpnH3D14_00067) 70345..70659 + 315 Protein_66 integrase -
LpnH3D14_RS00340 (LpnH3D14_00068) 70690..71994 - 1305 WP_032830606.1 type II toxin-antitoxin system HipA family toxin Toxin
LpnH3D14_RS00345 (LpnH3D14_00069) 71988..72227 - 240 WP_014840730.1 helix-turn-helix domain-containing protein Antitoxin
LpnH3D14_RS00350 (LpnH3D14_00070) 72321..72550 + 230 Protein_69 hypothetical protein -
LpnH3D14_RS00355 (LpnH3D14_00071) 72879..73244 + 366 WP_032830616.1 TraK family protein -
LpnH3D14_RS00360 (LpnH3D14_00072) 73245..73466 + 222 WP_042755330.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 435 a.a.        Molecular weight: 49634.93 Da        Isoelectric Point: 7.7618

>T266736 WP_032830606.1 NZ_CP114576:c71994-70690 [Legionella pneumophila]
MVMRKLYILMNNELVGELTQDNAGGLSFSYVADWISKPHSRPVSLSLPLVNQRFSGEVVYNFFDNLLPDNPQIRARIQAR
FQAKSSRPFDLLALIGGDCVGAIQIVERIPQTQRLSIESHVVSEAEIARTLRSYQTSPLGMDKEDDEFRISIAGAQEKTA
FLYYQNEWHKPFGPTPTTHIFKLPIGYLPHQGIDLSESCENEHLCLLLASKFGLEVAKSKILQFEDEKVLVVERFDRKWS
RDNRYILRLPQEDLCQALGYSPNLKYQSDGGPGIKEIMQLLNGSQQPQKDRDEFFRAQVVYWCLGAIDAHAKNFSISIQP
QGGYQLTPLYDIISAYPIVEQKQLSFKKLKMAMALYGKNSHYKIDGIQKRHFIETAKYVQYSKIKAAQIFEQVIDRIDSA
IDEVSTQLPNHFPEKIADPIFKGMRAFKERMIST

Download         Length: 1305 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9096.40 Da        Isoelectric Point: 5.0774

>AT266736 WP_014840730.1 NZ_CP114576:c72227-71988 [Legionella pneumophila]
MIISSAKDLALYLNDKRKQLKMSQSEVADLVGLKQDTISKFENSPDNSRIDTLFRILSALNLNMSLVEKDQKTHEEIEW

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References