Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 4786251..4786867 Replicon chromosome
Accession NZ_CP114571
Organism Enterobacter hormaechei strain E1532

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag O2601_RS23305 Protein ID WP_015569913.1
Coordinates 4786251..4786622 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A6G4MTK3
Locus tag O2601_RS23310 Protein ID WP_015569912.1
Coordinates 4786625..4786867 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O2601_RS23290 (O2601_23290) 4783751..4784653 + 903 WP_014072386.1 formate dehydrogenase subunit beta -
O2601_RS23295 (O2601_23295) 4784650..4785285 + 636 WP_015569914.1 formate dehydrogenase cytochrome b556 subunit -
O2601_RS23300 (O2601_23300) 4785282..4786211 + 930 WP_003861956.1 formate dehydrogenase accessory protein FdhE -
O2601_RS23305 (O2601_23305) 4786251..4786622 - 372 WP_015569913.1 PIN domain-containing protein Toxin
O2601_RS23310 (O2601_23310) 4786625..4786867 - 243 WP_015569912.1 ribbon-helix-helix domain-containing protein Antitoxin
O2601_RS23315 (O2601_23315) 4787066..4787986 + 921 WP_015569911.1 alpha/beta hydrolase -
O2601_RS23320 (O2601_23320) 4787995..4788936 - 942 WP_015569910.1 fatty acid biosynthesis protein FabY -
O2601_RS23325 (O2601_23325) 4788981..4789418 - 438 WP_015569909.1 D-aminoacyl-tRNA deacylase -
O2601_RS23330 (O2601_23330) 4789415..4790296 - 882 WP_003861949.1 virulence factor BrkB family protein -
O2601_RS23335 (O2601_23335) 4790290..4790889 - 600 WP_003861947.1 glucose-1-phosphatase -
O2601_RS23340 (O2601_23340) 4791008..4791808 - 801 WP_003861944.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13767.90 Da        Isoelectric Point: 6.4882

>T266732 WP_015569913.1 NZ_CP114571:c4786622-4786251 [Enterobacter hormaechei]
MEHMAVFDTNILIDLFNNRIEAADAIEHTASHRAISLITWMEVMVSARRHGHEAKTAAVMGAFEIIDVSRDIAERSVLLR
EKHGMKLPDAIILATAQSRKCPLISRNTKDFAGIDEVLTPYQV

Download         Length: 372 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9440.72 Da        Isoelectric Point: 4.4076

>AT266732 WP_015569912.1 NZ_CP114571:c4786867-4786625 [Enterobacter hormaechei]
MSVLAELDMGRILIDLSDDVIQRLDNLKQLRNQPRAELLREAIELYLDQQSSSVIRNALGLWGDRKEDGLEYERKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6G4MTK3

References