Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3875432..3876089 Replicon chromosome
Accession NZ_CP114571
Organism Enterobacter hormaechei strain E1532

Toxin (Protein)


Gene name cptA Uniprot ID A0A179PSF7
Locus tag O2601_RS18900 Protein ID WP_017382887.1
Coordinates 3875432..3875842 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag O2601_RS18905 Protein ID WP_003863437.1
Coordinates 3875823..3876089 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O2601_RS18880 (O2601_18880) 3871430..3873163 - 1734 WP_023304383.1 single-stranded-DNA-specific exonuclease RecJ -
O2601_RS18885 (O2601_18885) 3873169..3873882 - 714 WP_023295380.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
O2601_RS18890 (O2601_18890) 3873911..3874807 - 897 WP_023304385.1 site-specific tyrosine recombinase XerD -
O2601_RS18895 (O2601_18895) 3874909..3875430 + 522 WP_015571793.1 flavodoxin FldB -
O2601_RS18900 (O2601_18900) 3875432..3875842 - 411 WP_017382887.1 protein YgfX Toxin
O2601_RS18905 (O2601_18905) 3875823..3876089 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
O2601_RS18910 (O2601_18910) 3876384..3877364 + 981 WP_022649306.1 tRNA-modifying protein YgfZ -
O2601_RS18915 (O2601_18915) 3877476..3878135 - 660 WP_003863433.1 hemolysin III family protein -
O2601_RS18920 (O2601_18920) 3878402..3879133 + 732 WP_015571796.1 MurR/RpiR family transcriptional regulator -
O2601_RS18925 (O2601_18925) 3879250..3880683 + 1434 WP_017382891.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T266731 WP_017382887.1 NZ_CP114571:c3875842-3875432 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT266731 WP_003863437.1 NZ_CP114571:c3876089-3875823 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A179PSF7

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References