Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 1750704..1751492 Replicon chromosome
Accession NC_017342
Organism Staphylococcus aureus subsp. aureus TCH60

Toxin (Protein)


Gene name - Uniprot ID A0A2I7Y5B3
Locus tag HMPREF0772_RS08880 Protein ID WP_000525004.1
Coordinates 1750704..1751165 (-) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0E7YIA0
Locus tag HMPREF0772_RS08885 Protein ID WP_000333630.1
Coordinates 1751178..1751492 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HMPREF0772_RS08860 1747784..1748989 - 1206 WP_000264747.1 site-specific integrase -
HMPREF0772_RS08865 1749115..1749729 + 615 WP_000191459.1 hypothetical protein -
HMPREF0772_RS08870 1749726..1749872 - 147 WP_001013104.1 hypothetical protein -
HMPREF0772_RS08875 1750102..1750686 - 585 WP_000825948.1 hypothetical protein -
HMPREF0772_RS08880 1750704..1751165 - 462 WP_000525004.1 hypothetical protein Toxin
HMPREF0772_RS08885 1751178..1751492 - 315 WP_000333630.1 helix-turn-helix domain-containing protein Antitoxin
HMPREF0772_RS08890 1751644..1751880 + 237 WP_001121027.1 helix-turn-helix domain-containing protein -
HMPREF0772_RS08895 1751894..1752670 + 777 WP_001148544.1 Rha family transcriptional regulator -
HMPREF0772_RS08900 1752699..1752842 + 144 WP_000939498.1 hypothetical protein -
HMPREF0772_RS08905 1752832..1753041 - 210 WP_000642492.1 hypothetical protein -
HMPREF0772_RS08910 1753097..1753342 + 246 WP_001025401.1 DUF2829 domain-containing protein -
HMPREF0772_RS08915 1753311..1753676 - 366 WP_001128433.1 hypothetical protein -
HMPREF0772_RS08920 1753731..1753946 + 216 WP_001036302.1 hypothetical protein -
HMPREF0772_RS08925 1753971..1754234 + 264 WP_001124190.1 helix-turn-helix domain-containing protein -
HMPREF0772_RS08930 1754247..1754408 + 162 WP_001285963.1 DUF1270 family protein -
HMPREF0772_RS08935 1754487..1754810 + 324 WP_000175000.1 hypothetical protein -
HMPREF0772_RS08940 1754825..1755187 + 363 WP_000279449.1 hypothetical protein -
HMPREF0772_RS08945 1755184..1756350 + 1167 WP_000762532.1 DUF2800 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - lukS-PV / lukF-PV 1744780..1793870 49090


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18074.46 Da        Isoelectric Point: 4.6915

>T26673 WP_000525004.1 NC_017342:c1751165-1750704 [Staphylococcus aureus subsp. aureus TCH60]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T26673 NC_017342:c1751165-1750704 [Staphylococcus aureus subsp. aureus TCH60]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTGGA
TGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGCTTATCAGATAGAGAAAAGGCAGGAATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGG
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAAGCTTACAATTATGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTGCAATTGAGTGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGGACTC
ACTACGGCGAATACTCAATTACATTTGAGCCATTGAGAGTTTTTAAATATAAAGAAATATAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12063.56 Da        Isoelectric Point: 6.4736

>AT26673 WP_000333630.1 NC_017342:c1751492-1751178 [Staphylococcus aureus subsp. aureus TCH60]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Download         Length: 315 bp

>AT26673 NC_017342:c1751492-1751178 [Staphylococcus aureus subsp. aureus TCH60]
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTGGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAGCGTTATGAAAGCGGAAATATCAAAAATTTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCATATTTAATGGGGTGGGTTGAAGAAAACGATGATGAAGTACAACATCGTGCAGCTCACCTT
GAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGCAAACGTAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y5B3

Antitoxin

Source ID Structure
AlphaFold DB A0A0E7YIA0

References