Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2390628..2391367 Replicon chromosome
Accession NZ_CP114571
Organism Enterobacter hormaechei strain E1532

Toxin (Protein)


Gene name tacT Uniprot ID A0A822W909
Locus tag O2601_RS11635 Protein ID WP_017382345.1
Coordinates 2390628..2391113 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag O2601_RS11640 Protein ID WP_003857131.1
Coordinates 2391101..2391367 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O2601_RS11610 (O2601_11610) 2386115..2387083 - 969 WP_013815099.1 IS5-like element IS903B family transposase -
O2601_RS11615 (O2601_11615) 2387115..2387486 - 372 Protein_2268 transposase -
O2601_RS11620 (O2601_11620) 2387561..2388193 + 633 WP_001567369.1 hypothetical protein -
O2601_RS11625 (O2601_11625) 2388222..2389625 - 1404 WP_001567368.1 ISNCY-like element ISKpn21 family transposase -
O2601_RS11630 (O2601_11630) 2390008..2390577 + 570 WP_017382346.1 hypothetical protein -
O2601_RS11635 (O2601_11635) 2390628..2391113 - 486 WP_017382345.1 GNAT family N-acetyltransferase Toxin
O2601_RS11640 (O2601_11640) 2391101..2391367 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
O2601_RS11645 (O2601_11645) 2391431..2392360 - 930 WP_023303744.1 LysR family transcriptional regulator -
O2601_RS11650 (O2601_11650) 2392490..2393878 + 1389 WP_032619651.1 MFS transporter -
O2601_RS11655 (O2601_11655) 2393900..2394895 - 996 WP_023303746.1 DUF2891 domain-containing protein -
O2601_RS11660 (O2601_11660) 2394905..2395891 - 987 WP_017382341.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage aph(3')-Ia - 2378977..2391367 12390


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17510.21 Da        Isoelectric Point: 9.9658

>T266723 WP_017382345.1 NZ_CP114571:c2391113-2390628 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARAFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT266723 WP_003857131.1 NZ_CP114571:c2391367-2391101 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A822W909

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References