Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1106382..1107002 Replicon chromosome
Accession NZ_CP114571
Organism Enterobacter hormaechei strain E1532

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag O2601_RS05280 Protein ID WP_015571250.1
Coordinates 1106382..1106600 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag O2601_RS05285 Protein ID WP_006809850.1
Coordinates 1106628..1107002 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O2601_RS05250 (O2601_05250) 1102394..1102654 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
O2601_RS05255 (O2601_05255) 1102657..1102797 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
O2601_RS05260 (O2601_05260) 1102794..1103504 - 711 WP_023303201.1 GNAT family protein -
O2601_RS05265 (O2601_05265) 1103606..1105066 + 1461 WP_032620143.1 PLP-dependent aminotransferase family protein -
O2601_RS05270 (O2601_05270) 1105038..1105505 - 468 WP_017383209.1 YlaC family protein -
O2601_RS05275 (O2601_05275) 1105622..1106173 - 552 WP_023303203.1 maltose O-acetyltransferase -
O2601_RS05280 (O2601_05280) 1106382..1106600 - 219 WP_015571250.1 HHA domain-containing protein Toxin
O2601_RS05285 (O2601_05285) 1106628..1107002 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
O2601_RS05290 (O2601_05290) 1107513..1110659 - 3147 WP_015571248.1 multidrug efflux RND transporter permease subunit AcrB -
O2601_RS05295 (O2601_05295) 1110682..1111875 - 1194 WP_017694395.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T266722 WP_015571250.1 NZ_CP114571:c1106600-1106382 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT266722 WP_006809850.1 NZ_CP114571:c1107002-1106628 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References