Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 2636821..2637420 Replicon chromosome
Accession NZ_CP114550
Organism Xylella fastidiosa subsp. pauca strain AM2-Angelina

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag O4445_RS12125 Protein ID WP_228762756.1
Coordinates 2637133..2637420 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9P9V8
Locus tag O4445_RS12120 Protein ID WP_010895177.1
Coordinates 2636821..2637129 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O4445_RS12085 (O4445_12085) 2633405..2634166 - 762 WP_010895174.1 Bax inhibitor-1/YccA family protein -
O4445_RS12110 (O4445_12110) 2634967..2635161 + 195 WP_069107173.1 hypothetical protein -
O4445_RS12115 (O4445_12115) 2635361..2636755 + 1395 WP_109161026.1 hypothetical protein -
O4445_RS12120 (O4445_12120) 2636821..2637129 - 309 WP_010895177.1 putative addiction module antidote protein Antitoxin
O4445_RS12125 (O4445_12125) 2637133..2637420 - 288 WP_228762756.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
O4445_RS12130 (O4445_12130) 2637516..2638286 + 771 WP_010895179.1 hypothetical protein -
O4445_RS12135 (O4445_12135) 2638286..2638552 + 267 WP_023907141.1 hypothetical protein -
O4445_RS12140 (O4445_12140) 2639011..2639404 - 394 Protein_2369 DUF596 domain-containing protein -
O4445_RS12145 (O4445_12145) 2639416..2639670 - 255 WP_010895183.1 hemagglutinin -
O4445_RS12150 (O4445_12150) 2639944..2640327 - 384 WP_031338086.1 DUF596 domain-containing protein -
O4445_RS12155 (O4445_12155) 2640339..2640641 - 303 WP_152527175.1 DUF769 domain-containing protein -
O4445_RS12160 (O4445_12160) 2640840..2641232 - 393 WP_167701479.1 DUF596 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2635361..2638552 3191


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-94)

Antitoxin

Uncharacterized protein HI1420

(15-100)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10939.63 Da        Isoelectric Point: 10.3074

>T266708 WP_228762756.1 NZ_CP114550:c2637420-2637133 [Xylella fastidiosa subsp. pauca]
VKRLEEFSDWLKGLKDGLARQRLIKRLRKVQLGNFGDVQPVGEGVFEMREHFGPGWRMYYVQRGSFLIVMLGGGDKSTQQ
SDIRRAIELAKSLED

Download         Length: 288 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11038.60 Da        Isoelectric Point: 4.6561

>AT266708 WP_010895177.1 NZ_CP114550:c2637129-2636821 [Xylella fastidiosa subsp. pauca]
VTITKKINVSELPEFDAAEYLSSEEEVAAYLTAVLEENDPALLAAALGDIARSRGMSQIAKDSGITREGLYKALRPGSEP
RFDTISRVCTALGIRLVAQPMR

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1S0V409

References