Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 1843205..1843746 Replicon chromosome
Accession NZ_CP114550
Organism Xylella fastidiosa subsp. pauca strain AM2-Angelina

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag O4445_RS08685 Protein ID WP_282454387.1
Coordinates 1843205..1843528 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q9PCB8
Locus tag O4445_RS08690 Protein ID WP_010894329.1
Coordinates 1843525..1843746 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O4445_RS08655 (O4445_08655) 1839119..1839526 + 408 WP_088371303.1 DUF4124 domain-containing protein -
O4445_RS08660 (O4445_08660) 1839552..1839785 - 234 WP_058569894.1 hypothetical protein -
O4445_RS08665 (O4445_08665) 1840047..1840877 + 831 WP_282454383.1 site-specific integrase -
O4445_RS08670 (O4445_08670) 1840858..1841310 - 453 WP_282454384.1 DUF3693 domain-containing protein -
O4445_RS08675 (O4445_08675) 1841441..1842622 + 1182 WP_282454385.1 replication initiation factor domain-containing protein -
O4445_RS08680 (O4445_08680) 1842609..1842932 + 324 WP_282454386.1 hypothetical protein -
O4445_RS08685 (O4445_08685) 1843205..1843528 - 324 WP_282454387.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
O4445_RS08690 (O4445_08690) 1843525..1843746 - 222 WP_010894329.1 antitoxin MazE family protein Antitoxin
O4445_RS08695 (O4445_08695) 1844406..1845248 - 843 WP_228762888.1 methylisocitrate lyase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1839839..1843840 4001


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-103)

Antitoxin

Antitoxin MazE-like

(9-72)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 11743.79 Da        Isoelectric Point: 7.9831

>T266706 WP_282454387.1 NZ_CP114550:c1843528-1843205 [Xylella fastidiosa subsp. pauca]
MIQRGDLVTVSLQGDYGKPRPALIVQSDLLTELDSVALCPVTSDLRNAIFRVTVEPTAANGLRTLSQVMVDKISTLPRNK
ISEPFGRLNDEKMKAIERALLLIIGII

Download         Length: 324 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8426.53 Da        Isoelectric Point: 7.3606

>AT266706 WP_010894329.1 NZ_CP114550:c1843746-1843525 [Xylella fastidiosa subsp. pauca]
MTSTHRPDSKIVHHREQMRAAGLRPVQLWVPDTRTPEFAAEIQSQCRALKGDQAEADALRFTEKAMTHIEDWK

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB Q9PCB8

References