Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1370762..1371538 Replicon chromosome
Accession NC_017342
Organism Staphylococcus aureus subsp. aureus TCH60

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag HMPREF0772_RS06940 Protein ID WP_000031108.1
Coordinates 1371386..1371538 (+) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A0D1IYN8
Locus tag HMPREF0772_RS06935 Protein ID WP_001251219.1
Coordinates 1370762..1371361 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HMPREF0772_RS06915 1366678..1368135 + 1458 WP_000649898.1 ABC transporter permease subunit -
HMPREF0772_RS06920 1368128..1368850 + 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
HMPREF0772_RS06925 1369001..1370128 + 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
HMPREF0772_RS06930 1370133..1370603 + 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
HMPREF0772_RS06935 1370762..1371361 + 600 WP_001251219.1 glucosamine-6-phosphate isomerase Antitoxin
HMPREF0772_RS06940 1371386..1371538 + 153 WP_000031108.1 hypothetical protein Toxin
HMPREF0772_RS06950 1372139..1372534 + 396 WP_000901019.1 hypothetical protein -
HMPREF0772_RS06955 1372730..1374115 + 1386 WP_000116227.1 class II fumarate hydratase -
HMPREF0772_RS06960 1374571..1375392 - 822 WP_000669380.1 RluA family pseudouridine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T26670 WP_000031108.1 NC_017342:1371386-1371538 [Staphylococcus aureus subsp. aureus TCH60]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T26670 NC_017342:1371386-1371538 [Staphylococcus aureus subsp. aureus TCH60]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACTGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATTTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22357.50 Da        Isoelectric Point: 5.1445

>AT26670 WP_001251219.1 NC_017342:1370762-1371361 [Staphylococcus aureus subsp. aureus TCH60]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT26670 NC_017342:1370762-1371361 [Staphylococcus aureus subsp. aureus TCH60]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACTGATCAAGCGCCAGTACTAGATGAATTAAAGAAAAATATTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACTGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTTGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
CGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1IYN8

References