266699

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) FicTA/Fic(toxin)
Location 1192106..1192902 Replicon chromosome
Accession NZ_CP114550
Organism Xylella fastidiosa subsp. pauca strain AM2-Angelina

Toxin (Protein)


Gene name VbhT Uniprot ID -
Locus tag O4445_RS05470 Protein ID WP_023907999.1
Coordinates 1192291..1192902 (+) Length 204 a.a.

Antitoxin (Protein)


Gene name VbhA Uniprot ID A0A060HF63
Locus tag O4445_RS05465 Protein ID WP_004087046.1
Coordinates 1192106..1192294 (+) Length 63 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O4445_RS05430 (O4445_05430) 1188590..1189516 - 927 WP_088371969.1 phage recombination protein Bet -
O4445_RS05435 (O4445_05435) 1189532..1189690 - 159 WP_282454502.1 hypothetical protein -
O4445_RS05440 (O4445_05440) 1189711..1189902 - 192 WP_088371617.1 hypothetical protein -
O4445_RS05445 (O4445_05445) 1189926..1190117 - 192 WP_010894147.1 hypothetical protein -
O4445_RS05450 (O4445_05450) 1190114..1190521 - 408 WP_088371615.1 hypothetical protein -
O4445_RS05455 (O4445_05455) 1190521..1190979 - 459 WP_023908001.1 hypothetical protein -
O4445_RS05460 (O4445_05460) 1190976..1191704 - 729 WP_023908000.1 hypothetical protein -
O4445_RS05465 (O4445_05465) 1192106..1192294 + 189 WP_004087046.1 antitoxin VbhA family protein Antitoxin
O4445_RS05470 (O4445_05470) 1192291..1192902 + 612 WP_023907999.1 Fic/DOC family protein Toxin
O4445_RS05475 (O4445_05475) 1192953..1193654 - 702 WP_282454503.1 helix-turn-helix transcriptional regulator -
O4445_RS05480 (O4445_05480) 1193731..1193976 + 246 WP_088371611.1 hypothetical protein -
O4445_RS05485 (O4445_05485) 1194156..1194545 - 390 WP_088371609.1 hypothetical protein -
O4445_RS05490 (O4445_05490) 1194673..1194861 + 189 WP_282454504.1 hypothetical protein -
O4445_RS05495 (O4445_05495) 1194891..1195106 + 216 WP_282454349.1 hypothetical protein -
O4445_RS05500 (O4445_05500) 1195103..1195486 + 384 WP_282454505.1 hypothetical protein -
O4445_RS05505 (O4445_05505) 1195690..1196802 + 1113 WP_282454524.1 Bro-N domain-containing protein -
O4445_RS05510 (O4445_05510) 1196799..1197089 + 291 Protein_1072 DUF1376 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1182321..1230099 47778


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(55-152)

Antitoxin

Antitoxin VbhA

(10-56)


Sequences

Toxin        


Download         Length: 204 a.a.        Molecular weight: 22919.68 Da        Isoelectric Point: 4.9434

>T266699 WP_023907999.1 NZ_CP114550:1192291-1192902 [Xylella fastidiosa subsp. pauca]
MKYAGDRGDPYLDSETGVLRNLLGIRDQGWLDKIESTLSFLRTSELRERPVKGKFDLAHLQEIHNRLFQDVYDWAGQIRQ
VEISKGNTMFAQQIAIQSAAQQIFGQLAKEQFLCGLDAEEFSKRAGDYLGEINVLHPFREGNGRTQREFIAQLAQRAGYR
IDWGVVSQADMIKASIDAYNGDSSGLASIIRDGISDQLFKDNE

Download         Length: 612 bp

Antitoxin


Download         Length: 63 a.a.        Molecular weight: 6855.80 Da        Isoelectric Point: 4.9859

>AT266699 WP_004087046.1 NZ_CP114550:1192106-1192294 [Xylella fastidiosa subsp. pauca]
MLTDHEKAERRAVVQSALASQRIEGLEPDAQAVVDAECWARGEMTIAAAVDQYKARVRLQMA

Download         Length: 189 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A060HF63

References