Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 2554925..2555437 Replicon chromosome
Accession NZ_CP114549
Organism Xylella fastidiosa subsp. pauca strain ALM4

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag O4444_RS11520 Protein ID WP_282459607.1
Coordinates 2555237..2555437 (-) Length 67 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9P9V8
Locus tag O4444_RS11515 Protein ID WP_010895177.1
Coordinates 2554925..2555233 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O4444_RS11480 (O4444_11480) 2551509..2552270 - 762 WP_010895174.1 Bax inhibitor-1/YccA family protein -
O4444_RS11505 (O4444_11505) 2553071..2553265 + 195 WP_069107173.1 hypothetical protein -
O4444_RS11510 (O4444_11510) 2553465..2554859 + 1395 WP_282459606.1 hypothetical protein -
O4444_RS11515 (O4444_11515) 2554925..2555233 - 309 WP_010895177.1 putative addiction module antidote protein Antitoxin
O4444_RS11520 (O4444_11520) 2555237..2555437 - 201 WP_282459607.1 hypothetical protein Toxin
O4444_RS11525 (O4444_11525) 2555620..2556390 + 771 WP_010895179.1 hypothetical protein -
O4444_RS11530 (O4444_11530) 2556390..2556656 + 267 WP_282459608.1 hypothetical protein -
O4444_RS11535 (O4444_11535) 2557115..2557508 - 394 Protein_2248 DUF596 domain-containing protein -
O4444_RS11540 (O4444_11540) 2557520..2557774 - 255 WP_010895183.1 hemagglutinin -
O4444_RS11545 (O4444_11545) 2558048..2558431 - 384 WP_031338086.1 DUF596 domain-containing protein -
O4444_RS11550 (O4444_11550) 2558443..2558745 - 303 WP_152527175.1 DUF769 domain-containing protein -
O4444_RS11555 (O4444_11555) 2558944..2559336 - 393 WP_167701479.1 DUF596 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2545108..2566108 21000


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(2-65)

Antitoxin

Uncharacterized protein HI1420

(15-100)


Sequences

Toxin        


Download         Length: 67 a.a.        Molecular weight: 7404.38 Da        Isoelectric Point: 4.9306

>T266695 WP_282459607.1 NZ_CP114549:c2555437-2555237 [Xylella fastidiosa subsp. pauca]
VQLGNFGDVQPVGEGVFEMREHFGPGWRMYYVQRGSFLIVMLGGGDKSTQQSDIRRAIELAKSLED

Download         Length: 201 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11038.60 Da        Isoelectric Point: 4.6561

>AT266695 WP_010895177.1 NZ_CP114549:c2555233-2554925 [Xylella fastidiosa subsp. pauca]
VTITKKINVSELPEFDAAEYLSSEEEVAAYLTAVLEENDPALLAAALGDIARSRGMSQIAKDSGITREGLYKALRPGSEP
RFDTISRVCTALGIRLVAQPMR

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1S0V409

References