Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 1403318..1403910 Replicon chromosome
Accession NZ_CP114549
Organism Xylella fastidiosa subsp. pauca strain ALM4

Toxin (Protein)


Gene name PumA Uniprot ID Q9PD07
Locus tag O4444_RS06505 Protein ID WP_010894094.1
Coordinates 1403318..1403614 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag O4444_RS06510 Protein ID WP_004085592.1
Coordinates 1403617..1403910 (+) Length 98 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O4444_RS06475 (O4444_06475) 1398850..1399434 - 585 WP_010894101.1 glutathione peroxidase -
O4444_RS06480 (O4444_06480) 1399800..1399961 - 162 WP_010894100.1 hypothetical protein -
O4444_RS06485 (O4444_06485) 1400180..1401055 + 876 WP_023906641.1 ABC transporter ATP-binding protein -
O4444_RS06490 (O4444_06490) 1401052..1402029 + 978 WP_023906642.1 hypothetical protein -
O4444_RS06495 (O4444_06495) 1402271..1402717 + 447 WP_282459473.1 hypothetical protein -
O4444_RS06500 (O4444_06500) 1402917..1403123 + 207 WP_171817075.1 hypothetical protein -
O4444_RS06505 (O4444_06505) 1403318..1403614 + 297 WP_010894094.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
O4444_RS06510 (O4444_06510) 1403617..1403910 + 294 WP_004085592.1 putative addiction module antidote protein Antitoxin
O4444_RS06515 (O4444_06515) 1403966..1404319 - 354 WP_088372030.1 hypothetical protein -
O4444_RS06520 (O4444_06520) 1404316..1404957 - 642 WP_282459474.1 Gp138 family membrane-puncturing spike protein -
O4444_RS06525 (O4444_06525) 1404954..1405784 - 831 WP_282459475.1 hypothetical protein -
O4444_RS06530 (O4444_06530) 1405781..1406098 - 318 WP_023906646.1 hypothetical protein -
O4444_RS06535 (O4444_06535) 1406098..1406868 - 771 WP_282459476.1 hypothetical protein -
O4444_RS06540 (O4444_06540) 1407218..1407472 - 255 WP_282459477.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - pilT 1366580..1590125 223545


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 99 a.a.        Molecular weight: 11167.73 Da        Isoelectric Point: 9.8173

>T266693 WP_010894094.1 NZ_CP114549:1403318-1403614 [Xylella fastidiosa subsp. pauca]
MIELKQTDTFRKWREKLKDARARSAIASRLDRLAFGHVGDAEPVGKGVSELRINYGPGYRVYFQQRGDTIYLLLCGGDKG
LQARDIKTALHLSEQWSE

Download         Length: 297 bp


Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10246.59 Da        Isoelectric Point: 5.6232

>AT266693 WP_004085592.1 NZ_CP114549:1403617-1403910 [Xylella fastidiosa subsp. pauca]
MTEKLTSYDPAEDLTTDQAIADFMAAAFGTNDPAYVAHALGVVARAKGMTQIASQTGLSREQLYRSFSAEGNPTLRTTLA
VMKALGIELSAKPSGVH

Download         Length: 294 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A1S0V711


Antitoxin

Source ID Structure

References