Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1190707..1191350 Replicon chromosome
Accession NZ_CP114542
Organism Brevundimonas subvibrioides strain Br6

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag O3139_RS05945 Protein ID WP_269516070.1
Coordinates 1190940..1191350 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag O3139_RS05940 Protein ID WP_209321233.1
Coordinates 1190707..1190940 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O3139_RS05910 1185926..1186741 - 816 WP_269516066.1 hypothetical protein -
O3139_RS05915 1186883..1188832 - 1950 WP_269516418.1 transketolase -
O3139_RS05920 1188972..1189226 + 255 WP_269516067.1 hypothetical protein -
O3139_RS05925 1189226..1189543 + 318 WP_269516068.1 cell division protein ZapA -
O3139_RS05930 1189900..1190121 + 222 WP_269516069.1 hypothetical protein -
O3139_RS05935 1190136..1190675 + 540 WP_269516420.1 5-formyltetrahydrofolate cyclo-ligase -
O3139_RS05940 1190707..1190940 + 234 WP_209321233.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
O3139_RS05945 1190940..1191350 + 411 WP_269516070.1 PIN domain-containing protein Toxin
O3139_RS05950 1191347..1192171 + 825 WP_269516071.1 TIGR00282 family metallophosphoesterase -
O3139_RS05955 1192175..1192624 - 450 WP_269516072.1 DUF305 domain-containing protein -
O3139_RS05960 1192728..1194290 - 1563 WP_269516075.1 alkaline phosphatase D family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(9-56)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15098.23 Da        Isoelectric Point: 6.3301

>T266680 WP_269516070.1 NZ_CP114542:1190940-1191350 [Brevundimonas subvibrioides]
MSLFMVDTSVCIRALRGRSRVLLDRFQEEADRIAISSVVLMELLYGAAVSARPRHHRSEVEDFVDRLMVLDLDSEAAAHA
ADIKADLRAKGTPIGVHDTLIAGHARSRSAILITGNLNEFKRVDGLRCDDWPDTQT

Download         Length: 411 bp

>T266680 NZ_CP114542:1190940-1191350 [Brevundimonas subvibrioides]
ATGTCACTGTTCATGGTCGATACCAGCGTCTGTATCCGGGCGCTGAGAGGGCGTTCACGCGTATTGCTGGATCGCTTTCA
GGAAGAAGCAGACAGGATCGCCATCTCGTCGGTGGTCTTGATGGAACTGCTGTATGGCGCGGCGGTTTCGGCCCGCCCCC
GGCATCACAGGTCCGAGGTTGAAGACTTCGTCGATCGCCTGATGGTCCTGGATCTCGACTCTGAGGCTGCCGCCCACGCT
GCGGACATCAAGGCGGATCTACGCGCCAAGGGAACCCCGATCGGGGTTCACGACACCCTGATCGCCGGACATGCCAGAAG
TCGGAGTGCGATCCTGATCACGGGCAACCTCAACGAGTTCAAGCGGGTCGATGGCCTGCGGTGCGACGACTGGCCGGATA
CACAGACATGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8647.81 Da        Isoelectric Point: 4.2545

>AT266680 WP_209321233.1 NZ_CP114542:1190707-1190940 [Brevundimonas subvibrioides]
MTLPRATVFRTNRSQAIRIPKAVAFPDDVKELVAIREGRGLLLVPPDDVWTSFFNRPGIDIEEPEDPIDDSPPVSFD

Download         Length: 234 bp

>AT266680 NZ_CP114542:1190707-1190940 [Brevundimonas subvibrioides]
ATGACCCTGCCTCGCGCCACGGTATTCAGAACCAACCGCTCCCAGGCGATCCGCATCCCGAAAGCGGTGGCCTTTCCCGA
TGACGTCAAGGAGTTGGTCGCCATTCGGGAAGGACGGGGACTGTTGCTTGTTCCGCCGGATGATGTCTGGACGAGCTTCT
TCAACAGGCCGGGCATCGATATCGAAGAGCCGGAAGACCCGATCGACGATTCACCGCCGGTCAGCTTCGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References