266679

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1149111..1149718 Replicon chromosome
Accession NZ_CP114542
Organism Brevundimonas subvibrioides strain Br6

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag O3139_RS05705 Protein ID WP_269516032.1
Coordinates 1149111..1149365 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag O3139_RS05710 Protein ID WP_269516412.1
Coordinates 1149371..1149718 (+) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O3139_RS05690 1144638..1145672 - 1035 WP_269516029.1 ABC transporter substrate-binding protein -
O3139_RS05695 1146452..1147018 - 567 WP_269516030.1 hypothetical protein -
O3139_RS05700 1147094..1148944 - 1851 WP_269516031.1 ABC-F family ATP-binding cassette domain-containing protein -
O3139_RS05705 1149111..1149365 + 255 WP_269516032.1 type II toxin-antitoxin system HicA family toxin Toxin
O3139_RS05710 1149371..1149718 + 348 WP_269516412.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
O3139_RS05715 1149715..1150191 + 477 WP_269516413.1 YcgN family cysteine cluster protein -
O3139_RS05720 1150261..1152627 + 2367 WP_269516033.1 PAS domain S-box protein -
O3139_RS05725 1152624..1152992 + 369 WP_269516034.1 response regulator -
O3139_RS05730 1153105..1153548 + 444 WP_269516035.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-72)

Antitoxin

Uncharacterised protein family HicB

(51-101)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9201.60 Da        Isoelectric Point: 11.2769

>T266679 WP_269516032.1 NZ_CP114542:1149111-1149365 [Brevundimonas subvibrioides]
MNSKQTKTLAAVFADPVSGTIGWAAIENLLVAVGCHIVEGSGSRVRFVRGGEAEFFHRPHPAREARRYQVRAARAFLIRL
GVEP

Download         Length: 255 bp

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 12532.10 Da        Isoelectric Point: 5.2312

>AT266679 WP_269516412.1 NZ_CP114542:1149371-1149718 [Brevundimonas subvibrioides]
MTYKGYSAAVEFDADDEIFFGKLAGIRDGVGFHADTARELKAAFREAVDDYIETCARIGKSPDKPYSGKVMFRVDPEVHA
RVTKAAELSGRSLNAWAEDALRRAADADMAKAVAV

Download         Length: 348 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References