Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 4775924..4776566 Replicon chromosome
Accession NZ_CP114406
Organism Bacillus thuringiensis serovar tenebrionis strain NB-176

Toxin (Protein)


Gene name pemK Uniprot ID R8I8B8
Locus tag O3S71_RS24680 Protein ID WP_000635965.1
Coordinates 4775924..4776274 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag O3S71_RS24685 Protein ID WP_000004570.1
Coordinates 4776279..4776566 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O3S71_RS24665 4772860..4773318 - 459 WP_000343553.1 SprT family protein -
O3S71_RS24670 4773514..4773630 + 117 WP_001143640.1 cortex morphogenetic protein CmpA -
O3S71_RS24675 4773688..4775856 - 2169 WP_016078972.1 Tex family protein -
O3S71_RS24680 4775924..4776274 - 351 WP_000635965.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
O3S71_RS24685 4776279..4776566 - 288 WP_000004570.1 antitoxin EndoAI Antitoxin
O3S71_RS24690 4776875..4778044 - 1170 WP_000390595.1 alanine racemase -
O3S71_RS24695 4778162..4779112 - 951 WP_003306148.1 outer membrane lipoprotein carrier protein LolA -
O3S71_RS24700 4779269..4779628 - 360 WP_000583417.1 holo-ACP synthase -
O3S71_RS24705 4779722..4780294 + 573 WP_016078971.1 rhomboid family intramembrane serine protease -
O3S71_RS24710 4780287..4781249 - 963 WP_016078970.1 UV DNA damage repair endonuclease UvsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12948.04 Da        Isoelectric Point: 5.7168

>T266662 WP_000635965.1 NZ_CP114406:c4776274-4775924 [Bacillus thuringiensis serovar tenebrionis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMSRVDEALQISLGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT266662 WP_000004570.1 NZ_CP114406:c4776566-4776279 [Bacillus thuringiensis serovar tenebrionis]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A366G118

Antitoxin

Source ID Structure
AlphaFold DB A0A366FY90

References