Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2783752..2784730 Replicon chromosome
Accession NZ_CP114406
Organism Bacillus thuringiensis serovar tenebrionis strain NB-176

Toxin (Protein)


Gene name spoIISA Uniprot ID B7IX38
Locus tag O3S71_RS14340 Protein ID WP_000624981.1
Coordinates 2783993..2784730 (-) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID B7IX39
Locus tag O3S71_RS14335 Protein ID WP_000237817.1
Coordinates 2783752..2783880 (-) Length 43 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O3S71_RS14305 2779269..2779520 + 252 WP_000821942.1 LuxR C-terminal-related transcriptional regulator -
O3S71_RS14310 2779661..2780266 - 606 WP_000517276.1 hypothetical protein -
O3S71_RS14315 2780292..2781101 - 810 WP_016077711.1 papain-like cysteine protease family protein -
O3S71_RS14320 2781414..2782883 - 1470 WP_000287540.1 beta-Ala-His dipeptidase -
O3S71_RS14325 2783095..2783484 + 390 WP_000712655.1 YxeA family protein -
O3S71_RS14330 2783503..2783679 - 177 WP_000852629.1 stage II sporulation protein SB -
O3S71_RS14335 2783752..2783880 - 129 WP_000237817.1 hypothetical protein Antitoxin
O3S71_RS14340 2783993..2784730 - 738 WP_000624981.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
O3S71_RS14345 2784969..2785706 - 738 WP_000594159.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
O3S71_RS14350 2785872..2786354 - 483 WP_000191905.1 MarR family winged helix-turn-helix transcriptional regulator -
O3S71_RS14355 2786502..2788145 + 1644 WP_016077712.1 alpha-keto acid decarboxylase family protein -
O3S71_RS14360 2788303..2789085 - 783 WP_016077713.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(10-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28335.09 Da        Isoelectric Point: 8.2998

>T266661 WP_000624981.1 NZ_CP114406:c2784730-2783993 [Bacillus thuringiensis serovar tenebrionis]
MISNIRIGLFVLAIVFVVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNVFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

Antitoxin


Download         Length: 43 a.a.        Molecular weight: 4981.37 Da        Isoelectric Point: 3.9150

>AT266661 WP_000237817.1 NZ_CP114406:c2783880-2783752 [Bacillus thuringiensis serovar tenebrionis]
VVKDYDNDFFKEDNEDTTDFSLIKGDALQQVEELEEELKRKS

Download         Length: 129 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6D1SWF1

Antitoxin

Source ID Structure
AlphaFold DB B7IX39

References