Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1195037..1195566 Replicon chromosome
Accession NC_017342
Organism Staphylococcus aureus subsp. aureus TCH60

Toxin (Protein)


Gene name mazF Uniprot ID Q6GF05
Locus tag HMPREF0772_RS05915 Protein ID WP_000621176.1
Coordinates 1195204..1195566 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag HMPREF0772_RS05910 Protein ID WP_000948331.1
Coordinates 1195037..1195207 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HMPREF0772_RS05880 1190073..1190633 + 561 WP_001092414.1 K(+)-transporting ATPase subunit C -
HMPREF0772_RS05885 1190842..1191321 + 480 WP_001287082.1 hypothetical protein -
HMPREF0772_RS05890 1191314..1192891 + 1578 WP_001294645.1 PH domain-containing protein -
HMPREF0772_RS05895 1192884..1193375 + 492 WP_001286801.1 PH domain-containing protein -
HMPREF0772_RS05900 1193379..1193738 + 360 WP_000581197.1 holo-ACP synthase -
HMPREF0772_RS05905 1193804..1194952 + 1149 WP_001281140.1 alanine racemase -
HMPREF0772_RS05910 1195037..1195207 + 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
HMPREF0772_RS05915 1195204..1195566 + 363 WP_000621176.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
HMPREF0772_RS05925 1195916..1196917 + 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
HMPREF0772_RS05930 1197036..1197362 + 327 WP_001052491.1 anti-sigma factor antagonist -
HMPREF0772_RS05935 1197364..1197843 + 480 WP_001190825.1 anti-sigma B factor RsbW -
HMPREF0772_RS05940 1197818..1198588 + 771 WP_001041107.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13469.74 Da        Isoelectric Point: 10.1654

>T26666 WP_000621176.1 NC_017342:1195204-1195566 [Staphylococcus aureus subsp. aureus TCH60]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVVHQKN

Download         Length: 363 bp

>T26666 NC_017342:1195204-1195566 [Staphylococcus aureus subsp. aureus TCH60]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAACAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAGCAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACATACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGTTCATCAGAAAAATTAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT26666 WP_000948331.1 NC_017342:1195037-1195207 [Staphylococcus aureus subsp. aureus TCH60]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT26666 NC_017342:1195037-1195207 [Staphylococcus aureus subsp. aureus TCH60]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A168PYX0

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References