Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2783656..2784634 Replicon chromosome
Accession NZ_CP114399
Organism Bacillus thuringiensis serovar tenebrionis strain NB176-1

Toxin (Protein)


Gene name spoIISA Uniprot ID B7IX38
Locus tag O3S70_RS14290 Protein ID WP_000624981.1
Coordinates 2783897..2784634 (-) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID B7IX39
Locus tag O3S70_RS14285 Protein ID WP_000237817.1
Coordinates 2783656..2783784 (-) Length 43 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O3S70_RS14255 2779173..2779424 + 252 WP_000821942.1 LuxR C-terminal-related transcriptional regulator -
O3S70_RS14260 2779565..2780170 - 606 WP_000517276.1 hypothetical protein -
O3S70_RS14265 2780196..2781005 - 810 WP_016077711.1 papain-like cysteine protease family protein -
O3S70_RS14270 2781318..2782787 - 1470 WP_000287540.1 beta-Ala-His dipeptidase -
O3S70_RS14275 2782999..2783388 + 390 WP_000712655.1 YxeA family protein -
O3S70_RS14280 2783407..2783583 - 177 WP_000852629.1 stage II sporulation protein SB -
O3S70_RS14285 2783656..2783784 - 129 WP_000237817.1 hypothetical protein Antitoxin
O3S70_RS14290 2783897..2784634 - 738 WP_000624981.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
O3S70_RS14295 2784873..2785610 - 738 WP_000594159.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
O3S70_RS14300 2785776..2786258 - 483 WP_000191905.1 MarR family winged helix-turn-helix transcriptional regulator -
O3S70_RS14305 2786406..2788049 + 1644 WP_016077712.1 alpha-keto acid decarboxylase family protein -
O3S70_RS14310 2788207..2788989 - 783 WP_016077713.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(10-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28335.09 Da        Isoelectric Point: 8.2998

>T266659 WP_000624981.1 NZ_CP114399:c2784634-2783897 [Bacillus thuringiensis serovar tenebrionis]
MISNIRIGLFVLAIVFVVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNVFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

Antitoxin


Download         Length: 43 a.a.        Molecular weight: 4981.37 Da        Isoelectric Point: 3.9150

>AT266659 WP_000237817.1 NZ_CP114399:c2783784-2783656 [Bacillus thuringiensis serovar tenebrionis]
VVKDYDNDFFKEDNEDTTDFSLIKGDALQQVEELEEELKRKS

Download         Length: 129 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6D1SWF1

Antitoxin

Source ID Structure
AlphaFold DB B7IX39

References