Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2782362..2783340 Replicon chromosome
Accession NZ_CP114392
Organism Bacillus thuringiensis serovar tenebrionis strain NB125

Toxin (Protein)


Gene name spoIISA Uniprot ID B7IX38
Locus tag O3S72_RS14285 Protein ID WP_000624981.1
Coordinates 2782603..2783340 (-) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID B7IX39
Locus tag O3S72_RS14280 Protein ID WP_000237817.1
Coordinates 2782362..2782490 (-) Length 43 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O3S72_RS14250 2777879..2778130 + 252 WP_000821942.1 LuxR C-terminal-related transcriptional regulator -
O3S72_RS14255 2778271..2778876 - 606 WP_000517276.1 hypothetical protein -
O3S72_RS14260 2778902..2779711 - 810 WP_016077711.1 papain-like cysteine protease family protein -
O3S72_RS14265 2780024..2781493 - 1470 WP_000287540.1 beta-Ala-His dipeptidase -
O3S72_RS14270 2781705..2782094 + 390 WP_000712655.1 YxeA family protein -
O3S72_RS14275 2782113..2782289 - 177 WP_000852629.1 stage II sporulation protein SB -
O3S72_RS14280 2782362..2782490 - 129 WP_000237817.1 hypothetical protein Antitoxin
O3S72_RS14285 2782603..2783340 - 738 WP_000624981.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
O3S72_RS14290 2783579..2784316 - 738 WP_000594159.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
O3S72_RS14295 2784482..2784964 - 483 WP_000191905.1 MarR family winged helix-turn-helix transcriptional regulator -
O3S72_RS14300 2785112..2786755 + 1644 WP_016077712.1 alpha-keto acid decarboxylase family protein -
O3S72_RS14305 2786913..2787695 - 783 WP_016077713.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(10-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28335.09 Da        Isoelectric Point: 8.2998

>T266657 WP_000624981.1 NZ_CP114392:c2783340-2782603 [Bacillus thuringiensis serovar tenebrionis]
MISNIRIGLFVLAIVFVVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNVFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

Antitoxin


Download         Length: 43 a.a.        Molecular weight: 4981.37 Da        Isoelectric Point: 3.9150

>AT266657 WP_000237817.1 NZ_CP114392:c2782490-2782362 [Bacillus thuringiensis serovar tenebrionis]
VVKDYDNDFFKEDNEDTTDFSLIKGDALQQVEELEEELKRKS

Download         Length: 129 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6D1SWF1

Antitoxin

Source ID Structure
AlphaFold DB B7IX39

References