266654

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 24508..25030 Replicon plasmid pKP0155-1
Accession NZ_CP114376
Organism Klebsiella pneumoniae strain KP6870155

Toxin (Protein)


Gene name stbE Uniprot ID A0A9J6S4Z8
Locus tag NOZ09_RS26600 Protein ID WP_004187019.1
Coordinates 24746..25030 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A2J4ZSR4
Locus tag NOZ09_RS26595 Protein ID WP_004187025.1
Coordinates 24508..24756 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NOZ09_RS26565 (NOZ09_005156) 21875..22444 - 570 WP_004152117.1 small heat shock protein sHSP20 -
NOZ09_RS26570 22479..22760 - 282 WP_013307885.1 helix-turn-helix domain-containing protein -
NOZ09_RS26575 (NOZ09_005157) 23004..23267 - 264 WP_004118208.1 hypothetical protein -
NOZ09_RS26580 (NOZ09_005158) 23282..23545 + 264 WP_004187027.1 transposase -
NOZ09_RS26585 23490..23606 + 117 Protein_27 transposase domain-containing protein -
NOZ09_RS26590 23794..24218 + 425 Protein_28 IS1 family transposase -
NOZ09_RS26595 (NOZ09_005159) 24508..24756 + 249 WP_004187025.1 plasmid stabilization protein Antitoxin
NOZ09_RS26600 (NOZ09_005160) 24746..25030 + 285 WP_004187019.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NOZ09_RS26605 (NOZ09_005161) 25046..26401 - 1356 WP_087842581.1 ISNCY family transposase -
NOZ09_RS26610 26483..26734 - 252 Protein_32 conjugal transfer protein TraH -
NOZ09_RS26615 (NOZ09_005163) 27391..27804 - 414 WP_004187013.1 hypothetical protein -
NOZ09_RS26620 (NOZ09_005165) 29347..29811 + 465 WP_004187010.1 conjugative transfer protein MobI(A/C) -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..67306 67306


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11003.72 Da        Isoelectric Point: 10.5388

>T266654 WP_004187019.1 NZ_CP114376:24746-25030 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTLQVQFKKKLKERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYRVEDDIVTVTVIGVGK
RENDDIYNATLNRN

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9011.24 Da        Isoelectric Point: 3.9947

>AT266654 WP_004187025.1 NZ_CP114376:24508-24756 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFHAGDGAPVAILNRNEPAFYCVPPALYAQLMELLEDEELGRMADERSGEKVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4ZSR4

References