Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 10877..11613 Replicon plasmid pKP0155-1
Accession NZ_CP114376
Organism Klebsiella pneumoniae strain KP6870155

Toxin (Protein)


Gene name tacT Uniprot ID A0A8T5ZF70
Locus tag NOZ09_RS26505 Protein ID WP_004187044.1
Coordinates 10877..11359 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag NOZ09_RS26510 Protein ID WP_003026799.1
Coordinates 11347..11613 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NOZ09_RS26480 6903..7839 - 937 Protein_6 ISNCY family transposase -
NOZ09_RS26485 7949..8098 + 150 Protein_7 transposase -
NOZ09_RS26490 8114..8224 + 111 Protein_8 IS3 family transposase -
NOZ09_RS26495 (NOZ09_005145) 8456..9160 - 705 WP_031591821.1 toll/interleukin-1 receptor domain-containing protein -
NOZ09_RS26500 9320..10666 - 1347 WP_188201154.1 ISNCY family transposase -
NOZ09_RS26505 (NOZ09_005147) 10877..11359 - 483 WP_004187044.1 GNAT family N-acetyltransferase Toxin
NOZ09_RS26510 (NOZ09_005148) 11347..11613 - 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
NOZ09_RS26515 (NOZ09_005149) 11764..12468 + 705 WP_001067855.1 IS6-like element IS26 family transposase -
NOZ09_RS26520 (NOZ09_005150) 12627..15212 - 2586 WP_087842655.1 EAL domain-containing protein -
NOZ09_RS26525 15181..15426 - 246 WP_032238678.1 hypothetical protein -
NOZ09_RS26530 (NOZ09_005152) 15484..16464 - 981 Protein_16 IS5-like element ISKpn26 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..67306 67306
- inside IScluster/Tn - - 2795..16464 13669


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(46-148)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17280.93 Da        Isoelectric Point: 8.7197

>T266653 WP_004187044.1 NZ_CP114376:c11359-10877 [Klebsiella pneumoniae]
VGCITAPEPLSSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTYERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT266653 WP_003026799.1 NZ_CP114376:c11613-11347 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References