Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mosAT/AbiEii-AbiEi |
| Location | 4963289..4964970 | Replicon | chromosome |
| Accession | NZ_CP114375 | ||
| Organism | Klebsiella pneumoniae strain KP6870155 | ||
Toxin (Protein)
| Gene name | mosT | Uniprot ID | W8V1Q6 |
| Locus tag | NOZ09_RS24595 | Protein ID | WP_002885155.1 |
| Coordinates | 4963289..4964206 (-) | Length | 306 a.a. |
Antitoxin (Protein)
| Gene name | mosA | Uniprot ID | - |
| Locus tag | NOZ09_RS24600 | Protein ID | WP_048264886.1 |
| Coordinates | 4964212..4964970 (-) | Length | 253 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NOZ09_RS24575 (4958595) | 4958595..4960115 | + | 1521 | WP_048264887.1 | sugar ABC transporter ATP-binding protein | - |
| NOZ09_RS24580 (4960112) | 4960112..4961110 | + | 999 | WP_002885172.1 | ribose ABC transporter permease | - |
| NOZ09_RS24585 (4961141) | 4961141..4962082 | + | 942 | WP_002885156.1 | ABC transporter substrate-binding protein | - |
| NOZ09_RS24590 (4962157) | 4962157..4963164 | + | 1008 | WP_004177805.1 | carbohydrate kinase family protein | - |
| NOZ09_RS24595 (4963289) | 4963289..4964206 | - | 918 | WP_002885155.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| NOZ09_RS24600 (4964212) | 4964212..4964970 | - | 759 | WP_048264886.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
| NOZ09_RS24605 (4965056) | 4965056..4965784 | - | 729 | WP_002885152.1 | response regulator transcription factor | - |
| NOZ09_RS24610 (4966057) | 4966057..4968204 | + | 2148 | WP_077598858.1 | formate dehydrogenase subunit alpha | - |
| NOZ09_RS24615 (4968201) | 4968201..4968344 | - | 144 | WP_022631365.1 | hypothetical protein | - |
| NOZ09_RS24620 (4968782) | 4968782..4969468 | + | 687 | WP_065781944.1 | tetratricopeptide repeat protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 306 a.a. Molecular weight: 34687.15 Da Isoelectric Point: 5.4707
>T266652 WP_002885155.1 NZ_CP114375:c4964206-4963289 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
Download Length: 918 bp
Antitoxin
Download Length: 253 a.a. Molecular weight: 28504.92 Da Isoelectric Point: 10.1683
>AT266652 WP_048264886.1 NZ_CP114375:c4964970-4964212 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIALGAGKRQIVENGKFNAQ
YQITVPERFQKE
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIALGAGKRQIVENGKFNAQ
YQITVPERFQKE
Download Length: 759 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|