Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4804064..4804580 Replicon chromosome
Accession NZ_CP114375
Organism Klebsiella pneumoniae strain KP6870155

Toxin (Protein)


Gene name relE Uniprot ID A0A085DK79
Locus tag NOZ09_RS23785 Protein ID WP_009309309.1
Coordinates 4804064..4804348 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag NOZ09_RS23790 Protein ID WP_002886901.1
Coordinates 4804338..4804580 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NOZ09_RS23760 (4799548) 4799548..4799811 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
NOZ09_RS23765 (4799941) 4799941..4800114 + 174 Protein_4660 hypothetical protein -
NOZ09_RS23770 (4800117) 4800117..4800860 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
NOZ09_RS23775 (4801217) 4801217..4803355 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
NOZ09_RS23780 (4803596) 4803596..4804060 + 465 WP_032418146.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NOZ09_RS23785 (4804064) 4804064..4804348 - 285 WP_009309309.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NOZ09_RS23790 (4804338) 4804338..4804580 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NOZ09_RS23795 (4804658) 4804658..4806568 - 1911 WP_004152270.1 PRD domain-containing protein -
NOZ09_RS23800 (4806591) 4806591..4807745 - 1155 WP_002886900.1 lactonase family protein -
NOZ09_RS23805 (4807812) 4807812..4808552 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11141.99 Da        Isoelectric Point: 10.3787

>T266651 WP_009309309.1 NZ_CP114375:c4804348-4804064 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT266651 WP_002886901.1 NZ_CP114375:c4804580-4804338 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085DK79

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References