Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1174316..1174830 Replicon chromosome
Accession NC_017342
Organism Staphylococcus aureus subsp. aureus TCH60

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7U7IDH9
Locus tag HMPREF0772_RS05820 Protein ID WP_000581791.1
Coordinates 1174621..1174830 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag HMPREF0772_RS05815 Protein ID WP_000138934.1
Coordinates 1174316..1174609 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HMPREF0772_RS05790 1169678..1170319 + 642 WP_000483150.1 thiamine phosphate synthase -
HMPREF0772_RS05795 1170405..1171278 + 874 Protein_1097 membrane protein insertase YidC -
HMPREF0772_RS14520 1171435..1171734 - 300 WP_001793952.1 hypothetical protein -
HMPREF0772_RS05805 1171991..1172638 - 648 WP_001187612.1 HD domain-containing protein -
HMPREF0772_RS05810 1172666..1174150 - 1485 WP_000571563.1 cardiolipin synthase -
HMPREF0772_RS05815 1174316..1174609 + 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
HMPREF0772_RS05820 1174621..1174830 + 210 WP_000581791.1 heavy-metal-associated domain-containing protein Toxin
HMPREF0772_RS05825 1174958..1175095 + 138 WP_000828354.1 hypothetical protein -
HMPREF0772_RS15090 1175507..1176190 + 684 Protein_1104 transposase -
HMPREF0772_RS05835 1176351..1177553 - 1203 WP_001109939.1 rod shape-determining protein RodA -
HMPREF0772_RS05840 1177871..1178941 + 1071 WP_000159638.1 D-alanine--D-alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7826.83 Da        Isoelectric Point: 4.1008

>T26665 WP_000581791.1 NC_017342:1174621-1174830 [Staphylococcus aureus subsp. aureus TCH60]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVIINIIDGQVTVAYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T26665 NC_017342:1174621-1174830 [Staphylococcus aureus subsp. aureus TCH60]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGATTATTAATATAATAGACGGTCAGGTAACTGTAGCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT26665 WP_000138934.1 NC_017342:1174316-1174609 [Staphylococcus aureus subsp. aureus TCH60]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT26665 NC_017342:1174316-1174609 [Staphylococcus aureus subsp. aureus TCH60]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGACAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7IDH9

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References