Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2673629..2675217 Replicon chromosome
Accession NZ_CP114375
Organism Klebsiella pneumoniae strain KP6870155

Toxin (Protein)


Gene name hipA Uniprot ID A6T928
Locus tag NOZ09_RS13360 Protein ID WP_004176197.1
Coordinates 2673629..2674951 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag NOZ09_RS13365 Protein ID WP_002904790.1
Coordinates 2674951..2675217 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NOZ09_RS13345 (2668685) 2668685..2671186 + 2502 WP_087842418.1 fimbria/pilus outer membrane usher protein -
NOZ09_RS13350 (2671174) 2671174..2672178 + 1005 WP_032434525.1 fimbrial protein -
NOZ09_RS13355 (2672320) 2672320..2673612 + 1293 WP_269317191.1 glycoside hydrolase family 10 protein -
NOZ09_RS13360 (2673629) 2673629..2674951 - 1323 WP_004176197.1 type II toxin-antitoxin system HipA family toxin Toxin
NOZ09_RS13365 (2674951) 2674951..2675217 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NOZ09_RS13370 (2675483) 2675483..2675809 - 327 WP_002904788.1 hydroxyisourate hydrolase -
NOZ09_RS13375 (2675806) 2675806..2676306 - 501 WP_032434523.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
NOZ09_RS13380 (2676284) 2676284..2677663 - 1380 WP_004184021.1 nucleobase:cation symporter-2 family protein -
NOZ09_RS13385 (2678009) 2678009..2679163 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
NOZ09_RS13390 (2679144) 2679144..2680067 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49111.41 Da        Isoelectric Point: 7.5357

>T266648 WP_004176197.1 NZ_CP114375:c2674951-2673629 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT266648 WP_002904790.1 NZ_CP114375:c2675217-2674951 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6T928

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References