Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 814966..815623 Replicon chromosome
Accession NZ_CP114375
Organism Klebsiella pneumoniae strain KP6870155

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag NOZ09_RS04050 Protein ID WP_002916310.1
Coordinates 815213..815623 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag NOZ09_RS04045 Protein ID WP_002916312.1
Coordinates 814966..815232 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NOZ09_RS04020 (810122) 810122..811555 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
NOZ09_RS04025 (811674) 811674..812402 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
NOZ09_RS04030 (812452) 812452..812763 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
NOZ09_RS04035 (812927) 812927..813586 + 660 WP_002916317.1 hemolysin III family protein -
NOZ09_RS04040 (813737) 813737..814720 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
NOZ09_RS04045 (814966) 814966..815232 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
NOZ09_RS04050 (815213) 815213..815623 + 411 WP_002916310.1 protein YgfX Toxin
NOZ09_RS04055 (815630) 815630..816151 - 522 WP_004144730.1 flavodoxin FldB -
NOZ09_RS04060 (816252) 816252..817148 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
NOZ09_RS04065 (817171) 817171..817884 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NOZ09_RS04070 (817890) 817890..819623 + 1734 WP_032105216.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T266643 WP_002916310.1 NZ_CP114375:815213-815623 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT266643 WP_002916312.1 NZ_CP114375:814966-815232 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References