Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 4589666..4590252 Replicon chromosome
Accession NZ_CP114374
Organism Pseudomonas aeruginosa strain Jade-X

Toxin (Protein)


Gene name PumA Uniprot ID G8CP73
Locus tag O2604_RS21570 Protein ID WP_003120987.1
Coordinates 4589953..4590252 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag O2604_RS21565 Protein ID WP_003448662.1
Coordinates 4589666..4589956 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O2604_RS21545 (O2604_21545) 4585242..4587137 + 1896 WP_269315082.1 hypothetical protein -
O2604_RS21550 (O2604_21550) 4587134..4589110 + 1977 WP_180705078.1 DEAD/DEAH box helicase -
O2604_RS21555 (O2604_21555) 4589120..4589254 + 135 WP_259467026.1 hypothetical protein -
O2604_RS21560 (O2604_21560) 4589251..4589595 + 345 WP_003448665.1 hypothetical protein -
O2604_RS21565 (O2604_21565) 4589666..4589956 - 291 WP_003448662.1 putative addiction module antidote protein Antitoxin
O2604_RS21570 (O2604_21570) 4589953..4590252 - 300 WP_003120987.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
O2604_RS21575 (O2604_21575) 4590454..4591575 + 1122 WP_021205778.1 TcpQ domain-containing protein -
O2604_RS21580 (O2604_21580) 4591575..4593284 + 1710 WP_180705079.1 PilN family type IVB pilus formation outer membrane protein -
O2604_RS21585 (O2604_21585) 4593288..4594613 + 1326 WP_180705080.1 type 4b pilus protein PilO2 -
O2604_RS21590 (O2604_21590) 4594603..4595136 + 534 WP_059303264.1 type IV pilus biogenesis protein PilP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-90)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11133.88 Da        Isoelectric Point: 10.4495

>T266637 WP_003120987.1 NZ_CP114374:c4590252-4589953 [Pseudomonas aeruginosa]
MVEVKQTATFMAWESKLKDRRAKAVIAARIFRLANGLPGDVSPVGQGVSELRIHYGPGYRVYFQQRGTEIVILLCGGDKS
SQARDIEMAKRLANEWRPQ

Download         Length: 300 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10394.91 Da        Isoelectric Point: 4.7527

>AT266637 WP_003448662.1 NZ_CP114374:c4589956-4589666 [Pseudomonas aeruginosa]
MTEQIYDYDPAQALDSPEAMALFIADALDTGDTAYIAKAMGVVARAKGMTELAKETGLAREQLYKSFSERGNPTLKTMLA
VMRALGVDLTARPHAQ

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G8CP73

Antitoxin

Source ID Structure

References