266636

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4538586..4539844 Replicon chromosome
Accession NZ_CP114374
Organism Pseudomonas aeruginosa strain Jade-X

Toxin (Protein)


Gene name - Uniprot ID Q9I4U4
Locus tag O2604_RS21310 Protein ID WP_003112528.1
Coordinates 4538586..4539341 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag O2604_RS21315 Protein ID WP_003086329.1
Coordinates 4539476..4539844 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O2604_RS21300 (O2604_21300) 4533758..4536301 + 2544 WP_003112526.1 acyl-homoserine-lactone acylase QuiP -
O2604_RS21305 (O2604_21305) 4536456..4537817 - 1362 WP_003081943.1 DNA recombination protein RmuC -
O2604_RS21310 (O2604_21310) 4538586..4539341 - 756 WP_003112528.1 RES family NAD+ phosphorylase Toxin
O2604_RS21315 (O2604_21315) 4539476..4539844 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
O2604_RS21320 (O2604_21320) 4539917..4541203 - 1287 WP_003112529.1 FAD-binding oxidoreductase -
O2604_RS21325 (O2604_21325) 4541259..4542848 - 1590 WP_079986128.1 aldehyde dehydrogenase family protein -
O2604_RS21330 (O2604_21330) 4542927..4543403 + 477 WP_033944121.1 elongation factor GreAB -
O2604_RS21335 (O2604_21335) 4543406..4543681 - 276 WP_023088486.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28278.42 Da        Isoelectric Point: 7.7294

>T266636 WP_003112528.1 NZ_CP114374:c4539341-4538586 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT266636 WP_003086329.1 NZ_CP114374:c4539844-4539476 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9I4U4

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References