Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/- |
| Location | 3528866..3530087 | Replicon | chromosome |
| Accession | NZ_CP114374 | ||
| Organism | Pseudomonas aeruginosa strain Jade-X | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | O2604_RS16385 | Protein ID | WP_003114949.1 |
| Coordinates | 3529509..3530087 (+) | Length | 193 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | - |
| Locus tag | O2604_RS16380 | Protein ID | WP_003088112.1 |
| Coordinates | 3528866..3529420 (+) | Length | 185 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| O2604_RS16355 (O2604_16355) | 3524434..3524985 | + | 552 | WP_034038472.1 | XRE family transcriptional regulator | - |
| O2604_RS16360 (O2604_16360) | 3524982..3525380 | - | 399 | WP_003088123.1 | NADH-quinone oxidoreductase subunit A | - |
| O2604_RS16365 (O2604_16365) | 3525393..3525716 | - | 324 | WP_003102734.1 | multidrug efflux SMR transporter | - |
| O2604_RS16370 (O2604_16370) | 3526047..3526508 | + | 462 | WP_003102736.1 | (2Fe-2S)-binding protein | - |
| O2604_RS16375 (O2604_16375) | 3526513..3528708 | + | 2196 | WP_004349295.1 | xanthine dehydrogenase family protein molybdopterin-binding subunit | - |
| O2604_RS16380 (O2604_16380) | 3528866..3529420 | + | 555 | WP_003088112.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| O2604_RS16385 (O2604_16385) | 3529509..3530087 | + | 579 | WP_003114949.1 | HD domain-containing protein | Toxin |
| O2604_RS16390 (O2604_16390) | 3530195..3531382 | - | 1188 | WP_051488647.1 | HlyD family efflux transporter periplasmic adaptor subunit | - |
| O2604_RS16395 (O2604_16395) | 3531372..3533543 | - | 2172 | WP_042930112.1 | type I secretion system permease/ATPase | - |
| O2604_RS16400 (O2604_16400) | 3533533..3534810 | - | 1278 | WP_003102743.1 | TolC family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21897.75 Da Isoelectric Point: 5.3655
>T266635 WP_003114949.1 NZ_CP114374:3529509-3530087 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA
Download Length: 579 bp
Antitoxin
Download Length: 185 a.a. Molecular weight: 20454.63 Da Isoelectric Point: 8.1590
>AT266635 WP_003088112.1 NZ_CP114374:3528866-3529420 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
Download Length: 555 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|