Detailed information of TA system TA266634

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Acetyltransf_4(toxin)
• Location: 1820161..1821669
• Replicon: chromosome
• Accession: NZ_CP114374
• Organism: Pseudomonas aeruginosa strain Jade-X

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: O2604_RS08500
• Protein ID: WP_012613851.1
• Coordinates: 1820161..1820748 (+)
• Length: 196 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: O2604_RS08505
• Protein ID: WP_012613852.1
• Coordinates: 1820815..1821669 (+)
• Length: 285 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
O2604_RS08495 (O2604_08495)	1816416..1819895	-	3480	WP_003117605.1	PAS domain-containing hybrid sensor histidine kinase/response regulator	-
O2604_RS08500 (O2604_08500)	1820161..1820748	+	588	WP_012613851.1	GNAT family protein	Toxin
O2604_RS08505 (O2604_08505)	1820815..1821669	+	855	WP_012613852.1	AraC family transcriptional regulator	Antitoxin
O2604_RS08510 (O2604_08510)	1821766..1823931	+	2166	WP_003115567.1	TonB-dependent receptor family protein	-
O2604_RS08515 (O2604_08515)	1824106..1825980	+	1875	WP_003158329.1	MFS transporter	-
O2604_RS08520 (O2604_08520)	1826041..1826250	-	210	WP_003115568.1	cold-shock protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (20-152)

Antitoxin

• AraC-type arabinose-binding/dimerisation domain (19-151)

Sequences

Toxin

Protein

• Length: 196 a.a.
• Molecular weight: 21929.29 Da
• Isoelectric Point: 9.8676

>T266634 WP_012613851.1 NZ_CP114374:1820161-1820748 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAVLEASFTG

Nucleotide

• Length: 588 bp

Antitoxin

Protein

• Length: 285 a.a.
• Molecular weight: 31959.27 Da
• Isoelectric Point: 7.3276

>AT266634 WP_012613852.1 NZ_CP114374:1820815-1821669 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHADSLETQTRWRETVLALFRRH
ARLPEAPKAGQEPLPVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTIYE

Nucleotide

• Length: 855 bp